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Endocrine Abstracts

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20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

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ECE 2018, 19 - 22 May 2018; Barcelona, Spain

Plenary Lectures

Metabolic control of longevity

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Does therapy for thyroid dysfunction decrease mortality?
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ea0056pl7 | Metabolic control of longevity | ECE2018

Anti-obesity effect in mice and monkeys of partial inhibition of PI3Kα

Serrano Manuel

Partial inhibition of PI3K is one of the best-validated and evolutionary conserved manipulations to extend longevity. PI3K is a master regulator of anabolism and the best validated beneficial effects of reduced PI3K are related to metabolism and include increased energy expenditure, reduced nutrient storage, and protection from obesity. We have found that a dual chemical inhibitor of the α and δ PI3K isoforms (CNIO-PI3Ki) reduces obesity in mice and monkeys, without ...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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