Endocrine Abstracts

AutoImmune Thyroid Disease (AITD) is, nowadays, generally considered to be a complex multifactorial entity, in which the interplay between genetic and environmental factors results in the expression of the disease. Genetic predisposition plays a major role in the pathogenesis of AITD, as siblings and other family members of AITD patients are at increased risk for AITD. Then, how can we, as physicians, answer the question of our AITD patients ‘will my children also get the...

IgG4-related disease (IgG4-RD) is a fibro-inflammatory, immune-mediated, systemic disease usually presenting with tumefactive lesions and a subacute onset mimicking malignancy. A subset of autoimmune thyroid pathologic conditions can be incorporated in the spectrum of IgG4-RD. In some cases of Hashimoto’s Thyroiditis (HT) a rich IgG4-positive plasma cell infiltration has been described, and a marked storiform fibrosis is typical of the fibrotic variant of HT (FVHT) and of...

After treatment, hyperthyroidism will relapse in approximately half of the Graves’ diseases patients, and clinically relevant orbitopathy will develop in about 25% of the diseased. Therefore, predicting who will relapse or develop orbitopathy is both clinically important and contributes to understanding of the pathophysiology of the disease. To predict the risk of recurrence of hyperthyroidism, before the start of antithyroid drug therapy, GREAT (based on clinical markers...