Endocrine Abstracts

Introduction: Hypoxia is involved with various physiological activities from glucose metabolism to tumor suppression. Hypoxia-inducible factor (HIF) is known as master regulator of oxygen homeostasis that triggers more than 1,000 related gene expressions. When hypoxia occurs, HIF1a protein is stabilized and starts transcription. Mucin1 mediates the stabilization of HIF1a in a cytoplasm. In addition, cytoplasmic domain of mucin1 and HIf1a form a transcriptional complex at glyco...

Introduction: Tumor necrosis factor alpha (TNF-α) and Interleukin-6 (IL-6) are potent immunomodulators and proinflammatory cytokines displaying varied functions. Apart from monocytes/macrophages, they are also produced by the cells in female reproductive tract. Polycystic ovarian syndrome (PCOS) is one of the commonest endocrine disorder amongst women of reproductive age group. Several polymorphisms in the promoter region of the gene TNF-α, IL-6 and Leptin receptors ...

Introduction: Adipocytokines secreted by adipose tissue are suggested to play a role in the development of obesity-related complications. Leptin is mainly produced and secreted by adipose tissue and appears as an important regulator of energy balance. The relationship between leptin levels and energy expenditure remain unclear. Energy expenditure related to physical activity (PA) is the most variable part of total energy expenditure. There is some evidence tha...