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20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

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ECE 2018, 19 - 22 May 2018; Barcelona, Spain

ea0056p743 | Neuroendocrinology | ECE2018

Desensitization of the human motilin receptor by motilin and motilides

Matsuura Bunzo , Takano Akiko , Kawamura Tomoe , Yamamoto Shin , Senba Hidenori , Miyake Teruki , Furukawa Shinya , Abe Masanori , Hiasa Yoichi

The motilin receptor (MLNR) belongs to a family of Class I G protein-coupled receptors, and is an important endogenous regulator of gastrointestinal motor function. Motilin and erythromycin (EM), two chemically distinct full agonists of the motilin receptor, bind to distinct regions of this receptor, while the action of these different chemical classes of agonists likely yields a common activation state of the cytosolic face of this receptor that is responsible for interaction...

ea0056p744 | Neuroendocrinology | ECE2018

Clinical and radiological characteristics of patients with primary empty sella

Belaid Rym , Mchirgui Nadia , Rojbi Imen , Jaidane Amel , Nacef Ibtissem Ben , Khiari Karima , Ouertani Haroun , Abdallah Nejib Ben

Background: The primary empty sella (PES) is radiologically defined as partial when less than 50% of the sella is filled with cerebrospinal fluid (CSF) and pituitary gland thickness is ≥3 mm or total when more than 50% of the sella is filled with CSF and the gland thickness is ≤2 mm in diameter.The aim of our study was to evaluate clinical and radiological aspects of PES.Methods: We retrospectively evaluated clinical features and radiological...

ea0056p745 | Neuroendocrinology | ECE2018

Serum sodium is inversely related to frailty and bone mineral density (BMD) in human immunodeficiency virus (HIV)-infected patients

Vincentis Sara De , Decaroli Maria Chiara , Diazzi Chiara , Santi Daniele , Carli Federica , Zona Stefano , Guaraldi Giovanni , Rochira Vincenzo

Background: HIV-infected patients are predisposed to an increased risk of hyponatremia. In healthy population, low sodium is associated with impaired health status and reduced BMD, but less is known about this association in HIV-infection.Aim: To investigate the relationship between serum sodium, frailty and BMD in a large cohort of HIV-infected patients.Methodology: A retrospective, observational, cohort study on adult HIV-infecte...

ea0056p746 | Neuroendocrinology | ECE2018

Sox 2 expression in human pituitary adenomas-correlations with pituitary function

Capatina Cristina , Cimpeanu Anca , Raica Marius , Coculescu Mihail , Poiana Catalina

Introduction: Sox2 is a widely expressed marker of progenitor and stem cells in various organs, strongly expressed within Rathke’s pouch and the neural ectoderm. It exerts a critical role in the early stages of pituitary development but it is still expressed in the adult gland. Sox2 expression in pituitary adenomas and its possible correlation with clinicopathologic characteristics have not been investigated so far.Aim: To evaluate the immunohistoch...

ea0056p747 | Neuroendocrinology | ECE2018

The probability of recurrence of the Cushing’s disease within three years after surgical treatment depends on the ACTH and cortisol levels in early post-surgery period

Nadezhdina Elena , Rebrova Olga , Ivaschenko Oksana , Azizyan Vilen , Grigoriev Andrey

Objective: The search for the predictors of the Cushing’s disease (CD) recurrence after surgical treatment among the following parameters - gender, age, adenoma size, preoperative levels of ACTH (morning) and cortisol (evening) in the blood, postoperative levels of ACTH (morning) and cortisol (morning) in the blood.Material and methods: A retro- and prospective monocenter study of treatment outcomes in 181 patients with confirmed diagnosis of Cushin...

ea0056p748 | Neuroendocrinology | ECE2018

Metabolic status, body composition and bone mineral density in 85 patients with childhood onset growth hormone deficiency (COGHD) in transition period

Doknic Mirjana , Milenkovic Tatjana , Zdravkovic Vera , Jesic Maja , Todorovic Sladjana , Mitrovic Katarina , Vukovic Rade , Miljic Dragana , Pekic Sandra , Soldatovic Ivan , Stojanovic Marko , Petakov Milan

Transition from childhood to adulthood is particularly important in patients with COGHD mainly because of the associated metabolic abnormalities, inadequate body composition and decreased bone mineral density (BMD). There is a lack of large monocentric studies related to this issue.Design: Monocentric, observational, retrospective cross-sectional study.Patients: We collected 85 COGHD patients (58 males, aged 17–26 years) trans...

ea0056p749 | Neuroendocrinology | ECE2018

Latest safety outcomes from the PATRO adults study of omnitrope® for the treatment of adult patients with growth hormone deficiency

Beck-Peccoz Paolo , Hoybye Charlotte , Murray Robert , Simsek Suat , Zabransky Markus , Zouater Hichem , Stalla Gunter

Introduction: Omnitrope® (Sandoz) is a recombinant human growth hormone (rhGH) and was the first biosimilar medicine approved by the European Medicines Agency. PATRO Adults is an international, longitudinal, non-interventional study of the long-term safety and efficacy of Omnitrope® in adults treated in routine clinical practice. The study provides data on the long-term safety of rhGH in adult patients with severe GH deficiency (GHD). Here we pr...

ea0056p750 | Neuroendocrinology | ECE2018

The different response of somatotropic system to genistein and daidzein in the rat hypothalamus

Trifunovic Svetlana , Sosic-Jurjevic Branka , Manojlovic-Stojanoski Milica , Ristic Natasa , Nestorovic Natasa , Filipovic Branko , Milosevic Verica

The different response of somatotropic system to genistein and daidzein in the rat hypothalamus: Svetlana Trifunović, Branka Šošić-Jurjević, Milica Manojlović-Stojanoski, Nataša Ristić, Nataša Nestorović, Branko Filipović, Verica MiloševićUniversity of Belgrade, Institute for Biological Research ‘Siniša Stanković’, Department of Cytology, Belgrade, Serbia The different r...

ea0056p751 | Neuroendocrinology | ECE2018

Efficacy and safety of a combinated pasireotide lar, pegvisomant and cabergoline treatment in four cases of aggressive somatotrophinomas

Bima Chiara , Chiloiro Sabrina , Giampietro Antonella , Bianchi Antonio , Piacentini Serena , Milardi Domenico , Tartaglione Tommaso , Lauretti Liverana , Anile Carmelo , Pontecorvi Alfredo , Marinis Laura De

Introduction: A significant number of GH-secreting pituitary adenomas show an aggressive behavior, therefore, when uncontrolled acromegaly persists, a pharmaceutical combination may improve biochemical control, with reduction of disease morbidity and mortality. We aimed to describe the clinical features of four patients successfully treated with a pharmacological combination of pasireotide LAR, pegvisomant and cabergoline.Case reports: Acromegaly was dia...

ea0056p752 | Neuroendocrinology | ECE2018

Pediatric hyperprolactinemia: a review of 25 cases

Dagdeviren Cakir Aydilek , Turan Hande , Ercan Oya , Evliyaoglu Olcay

Objective: Hyperprolactinemia is a rare endocrine disorder in childhood, which may be due to various etiological factors and may present with different signs and symptoms. We aimed to evaluate the etiologic reasons, clinical features and outcome in hyperprolactinemia patients retrospectively.Method: Data from 25 patients who were followed up with hyperprolactinemia between years 2009 and 2017 were evaluated.Results: A total of 25 p...

ea0056p753 | Neuroendocrinology | ECE2018

Could predict the postoperative rosnance the acromegaly cure?

Rosa Alhambra Exposito Maria , Sagrario Lombardo Galera Maria , Rebollo Roman Angel , Angeles Galvez Moreno M.

Acromegaly is caused by excessive growth hormone (GH) secretion from pituitary adenomas. Transphenoidal surgery is the first-choice treatment, but new drug therapies (e.g. somatostatin analogs, SSA) offer promising avenues for medical treatment. Complementary diagnostic tools may assist this strategy, helping to refine drug choice. Here, we investigate the associations between postsurgical radiological features and molecular phenotype of pituitary tumors from acromegalic patie...

ea0056p754 | Neuroendocrinology | ECE2018

Initiation of tolvaptan therapy for mild/moderate chronic SIADH-induced hyponatremia in a day-ward

Ramos Elvira , Barrio Elvira , Miguel Paz de , Cuesta Martin , Fernandez Luzdivina , Victoria Saez de Parayuelo Maria , Maria Cruz Anba , Ortiz Marta , Calle Alfonso , Runkle Isabelle

Introduction: Tolvaptan is the only V2-receptor antagonist authorized for use in Europe in patients with SIADH. Its initiation requires hospitalization. Our goal was to analyze the safety and efficacy of tolvaptan started in a Hospital Day-Ward.Material and methods: Retrospective descriptive study of 33 ambulatory patients with mild/moderate SIADH-induced chronic sustained hyponatremia initiating tolvaptan therapy in the Day-Ward of a tertiary center ove...

ea0056p755 | Neuroendocrinology | ECE2018

Ki67 as a marker of recurrence in craniopharyngioma

Jesus Martinez Ortega Antonio , Maria Venegas Moreno Eva , Elena Dios Fuentes Maria , Jesus Remon Ruiz Pablo , Javier Marquez Rivas Francisco , Kaen Ariel , Cardenas Ruiz-Valdepenas Eugenio , David Cano Gonzalez Antonio , Manuel Soto Moreno Alfonso

Craniopharyngiomas (CP) are low-prevalent tumors characterized for their local invasiveness and poor clinical outcomes, often requiring aggressive therapeutic measures. Ki67 is a marker of proliferation with good correlation with tumor recurrence in many solid tumors but this relationship is unclear in CP. Our aim is to determine whether Ki67 could be a marker for recurrence in CP.Material and methods: Descriptive retrospective observational study. All p...

ea0056p756 | Neuroendocrinology | ECE2018

Pituitary abscesses diagnosis and therapeutic approach in a reference unit

Cozar Miriam , Venegas Eva , Dios Elena , Cano David , Madrazo Ainara , Remon Pablo , Jimenez Enrique , Roldan Florinda , Cardenas Eugenio , Kaen Ariel , Soto Alfonso

Introduction: Pituitary abscess (PA) is a rare condition, representing less than 1% of pituitary lessions. Only around 200 cases have been reported in the scientific literature. Preoperative diagnosis is often challenging due to nonspecific clinical and radiological manifestations.Materials and methods: Retrospective descriptive cohort study. We analyze demographic and clinical variables, hormonal involvement, recurrence, type of surgery and antibiotic t...

ea0056p757 | Neuroendocrinology | ECE2018

Efficacy and effectiveness of pegvisomant monotherapy in treatment patients with acromegaly – systematic review with meta-analysis

Borowiack Ewa , Borowiack Monika , Jarosz Joanna , Nowotarska Anna , Przeda-Machno Patrycja , Konopka-Pliszka Malgorzata

Objectives: The aim of this systematic review was assessment of clinical efficacy of pegvisomant (PEG) in the treatment of adult patients (age ≥18 years) with acromegaly.Methods: The review was conducted according to the Cochrane Collaboration guidelines and polish recommendations of The Agency for Health Technology Assessment and Tariff System. Since acromegaly is a rare disease, not only randomized clinical trials (RCTs), but also real world data...

ea0056p758 | Neuroendocrinology | ECE2018

The occurrence of hyperprolactinemia in a hormonally inactive pituitary adenoma

Safarova Mijgona , Ismailov Said , Khalimova Zamira , Khodjaeva Saida , Gumarova Aliya , Azimova Ozoda , Vodovskaya Aleksandra , Issaeva Saodat

Aim: The work was initiated to study prolactin levels in hormonally inactive pituitary adenoma by the size of the tumor.Material and methods: We examined 85 patients with hormonally inactive pituitary adenomas, 45 women and 40 men among them aged from 18 to 50 years (mean age 44.5±3.85 years). The disease duration from the onset to diagnosis based on the medical history and MRI ranged from 1 to 15 years.Results and discussion:...

ea0056p759 | Neuroendocrinology | ECE2018

Body composition and bone health in patients treated for craniopharyngioma: a retrospective 10 year follow-up study

van Santen Selvetta S. , Hammarstrand Casper , Olsson Daniel , Wijnen Mark , Johannsson Gudmundur , van der Lely Aart J. , Neggers Sebastian

Introduction: Craniopharyngiomas are benign tumors in the suprasellar region that have encouraging survival rates between 77-93%. Unfortunately, long-term sequelae are frequent, resulting in excessive endocrine and metabolic morbidity, including premature cardiovascular disease and reduced bone health.Objective: To determine the prevalence of unfavorable body composition and low bone mineral density (BMD) in patients with craniopharyngioma.<p class="...

ea0056p760 | Neuroendocrinology | ECE2018

Postoperative basal serum cortisol as a predictor of long-term hypothalamic-pituitary-adrenal axis integrity after endonasal transsphenoidal surgery for sellar and suprasellar masses

Males Maldonado David , Martin Alba , Librizzi Soledad , Martin-Arriscado Cristina , Paredes Igor , Fernandez Alen Jose , Lagares Alfonso , Aramendi Mercedes , Calatayud Maria

Introduction: Endonasal endoscopic transsphenoidal surgery (EETS) for a sellar or suprasellar mass poses potential complications, including transient or permanent hypopituitarism. Adrenocortical insufficiency is especially worrisome given its potentially life-threatening course, if untreated. Usual clinical practice includes administration of perioperative “stress doses” of steroids followed by long term steroid replacement until the hypothalamic-pituitary-adrenal ax...

ea0056p761 | Neuroendocrinology | ECE2018

Recurrence of hyperprolactinemia after dopamine agonists withdrawal

Contreras Pascual Cristina , Gonzalez Lazaro Paloma , Silva Fernandez Julia , Gomez Garcia Ines , Maria Torres Arroyo Belvis , del Val Zaballos Florentino , Javier Gomez Alfonso Francisco , Garcia Manzanares Vazquez Alvaro

Introduction: Prolactinomas are the most common tumors among functional pituitary adenomas and they constitute 40% of all pituitary tumors. Dopamine agonists (DA) are considered the primary treatment of prolactinoma. DA can lead to complete remission (including eradicacion of the tumor), allowing discotinuation of treatment. So far, there aren’t clinical criteria with sufficient predictive value for long-term remission.Objective: To assess the effec...

ea0056p762 | Neuroendocrinology | ECE2018

A case of impaired vision after cabergoline therapy of macroprolactinoma: case report

Delgado M , Jauregui N , Saenz S , Paz J , Alvarez L , Quintana O , Rojas Marialejandra Delgado , Ibarra Jose Luis Paz

Case report: A male 30 years old, presented with a 12-month history of retro-orbital and frontal headache, oppressive type of moderate intensity, which subsides with analgesics. Subsequently, deterioration of bilateral visual fields, predominantly left side, after that was investigated by a neurologist in INCN in January 2013. A magnetic resonance imaginig scan of the brain showed a 45×50 mm pituitary macroadenoma, with suprasellar extension bowing the optic chiasm and ca...

ea0056p763 | Neuroendocrinology | ECE2018

The levels of serum osmolality, sodium, and copeptin as predictors of the development of postoperative diabetes insipidus

Mikhaylova Daria , Dzeranova Larisa , Pigarova Ekaterina , Rozhinskaya Ludmila , Grigoriev Andrey , Azizyan Vilen , Ivashenko Oksana

Objective: To assess the levels of osmolality, sodium in blood and urine, and copeptin level in patients after transnasal adenomectomy for pituitary adenomas.Materials and methods: A total of 154 patients, aged 18 to 65 years, were included in this study and underwent transnasal adenomectomy. Surgical treatment was performed in 73 patients with Cushing’s disease, 66 – acromegaly, 4 – prolactinoma, 9 – hormonally inact...

ea0056p764 | Neuroendocrinology | ECE2018

Pregnancy outcomes in women with active acromegaly.

Vorotnikova Svetlana , Tarasova Arina , Pigarova Ekaterina , Lutsenko Alexander , Stanoevich Irina , Dzeranova Larisa

Growth hormone (GH) producing tumors are commonly associated with menstrual disorders and anovulation because of the direct effects of tumor mass on gonadotropins and possible association with hyperprolactinemia. However, some women with acromegaly get pregnant, which rises up a lot of questions about medication, complications and follow-up. We report outcomes of 7 cases of pregnancy in patients with active acromegaly. A median age of patients was 30 years, four of them were w...

ea0056p765 | Neuroendocrinology | ECE2018

Rathke’s cleft cyst mimiking pituitary apoplexy: a case report

Barka Ines , Bensmaine Faiza , Bah Moctar , Bouche Clara , Gautier Jean Francois

Introduction: The most common sellar lesions are mainly due to pituitary adenomas, craniopharyngiomas and benign cysts. Rathke’s cleft cyst (RCC) is a developmental sellar or suprasellar cystic lesion, which rarely becomes symptomatic. Here, we present an interesting case of intra sellar RCC, with a presenting feature of acute pituitary apoplexy.Case report: A 39 year old healthy women was referred to the emergency room for sudden headache and fatig...

ea0056p766 | Neuroendocrinology | ECE2018

Quality of life acromegalic patients based on the AcroQoL questionnaire

Pokramovich Yulia , Dreval Alexander , Ilovayskaya Irena , Gilyazova Aliya

Introduction: Acromegaly is a rare chronic disease caused by growth hormone (GH) and insulin-like growth factor 1 type (IRF-1) excess. However, reaching biochemical control of the disease does not always guarantee the improvement of symptoms that play a significant role in the quality of life associated with human health (HRQoL), in particular, patients with acromegaly.Goal: To investigate the quality of life in patients with acromegaly in the Moscow reg...

ea0056p767 | Neuroendocrinology | ECE2018

Female patients with acromegaly in Russian hypothalamic and pituitary tumors registry (OGGO)

Lutsenko Alexander , Vorotnikova Svetlana , Stanoevich Irina , Przhiyalkovskaya Elena , Pigarova Ekaterina , Rozhinskaya Liudmila , Belaya Zhanna

Aim: To assess the data of the registry concerning women with acromegaly.Materials and methods: Russian hypothalamic and pituitary tumors registry database, containing the information on 3968 acromegalic patients.Results: From all patients with acromegaly registered in the database, 2878 patients (72.5%) are women. We assessed the following data on gonadal status and reproductive function in this group: 512 patients have irregular ...

ea0056p768 | Neuroendocrinology | ECE2018

ACTH-secreting pituitary adenomas surgical outcomes and complications in Endoscopic transsphenoidal pituitary surgery (ETPS)

Remon-Ruiz Pablo , Dios-Fuentes Elena , Venegas Eva , Kaen Ariel , Cardenas Eugenio , Garcia Natividad , Roldan Florinda , Fajardo Elena , Cano David , Soto Alfonso

Methods: Descriptive retrospective study among patients who underwent ETPS for ACTH-secreting pituitary adenomas performed by the same surgical team from January/2013 to January/2017.Results: 27 ACTH-secreting pituitary adenomas operated via ETPS. 20 (74.1%) were women, median age at surgery was 43.25 [29.65–61.59] years and median follow-up was 3.13 [1.6–6.69] years. Presurgically, 25 (92.59%) patients recieved drugs for control cortisol hyper...

ea0056p769 | Neuroendocrinology | ECE2018

Clinical outcomes and complications in Endoscopic transsphenoidal pituitary surgery (ETPS) for Non-functioning pituitary adenomas

Remon-Ruiz Pablo , Dios Elena , Venegas Eva , Cardenas Eugenio , Kaen Ariel , Garcia Natividad , Roldan Florinda , Fajardo Elena , Cano David , Soto Alfonso

Methods: We conducted a retrospective descriptive study including 67 patients with non-functioning pituitary adenomas surgicaly removed via ETPS beetwen January/2013 to January/2017.Results: Among 67 patients with non-functioning pituitary adenomas surgicaly removed via ETPS 44 (65.67%) were men. 52 (77.61%) patients recieved their first surgery, 14 (20.9%) had been operated one time before and 1 (1.49%) had been operated two times. Every patient reopera...

ea0056p770 | Neuroendocrinology | ECE2018

Somatostatin analogues therapy of clinically non-functioning pituitary adenomas- impact on tumour volume and visual field

Bozena Zawada Natalia

Introduction: Surgery remains the first-line treatment of clinically non-functioning pituitary adenomas (NFPA). However, the presence of somatostatin receptors (SSTR) in these tumours forms the basis of clinical use of somatostatin analogues (SSA). Visualisation of SSTR in scintigraphy is compulsory to introduce SSA therapy in NFPA.Aim: To assess the effectiveness of long-term somatostatin analogues treatment on tumour volume and visual field in patients...