Endocrine Abstracts

Introduction: Contrary to the high prevalence of polycystic ovarian syndrome (PCOS) amongst reproductive age group women, there is disproportionate uncertainity over its etiopathogenesis. Substantial evidence suggests immunological-inflammatory role in causing this endocrine disorder. In this context, we set out study the role of inflammatory biomarkers in PCOS.Material and methods: This prospective case-control study was conducted on PCOS patients diagn...

Previous studies suggest that environmental factors such as high levels of meat consumption, caffeine, cigarette smoking, pesticides, and endocrine disrupting chemicals (EDCs) may enhance the risk of breast cancer. The fludioxonil is an antifungal agent used in agricultural applications and present at measurable amounts in fruits and vegetables. In this study, the effects of fludioxonil on cancer cell viability and migration ability were examined in MCF-7 and T47D breast cance...

Fenhexamid (Fen) and cyprodinil (Cyp) are antifungal agents used in agricultural applications. In this study, to examine the effects of two-pesticides on cancer cell viability and metastasis via estrogen receptor pathway, the ER positive-MCF-7 and ER negative-MDA-MB-231 breast cancer cells were used. MCF-7 and MDA-MB-231 were cultured with 0.1% DMSO (control), 17β-estradiol (E2; 1×10−9 M), Fen (10−5–10−7</s...

Objectives: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies in women. Its increasing prevalence is probably related to environmental estrogens exposure, such as bisphenol A (BPA). BPA is considered to play an important role in the ethiopathogenesis of PCOS and can be responsible for various clinical symptoms. Aim of the study was to compare the levels of urinary BPA between PCOS women and healthy controls and to assess the relationship of BPA to sex...

Background: Cross-sex hormone therapy (CHT) is known to lead to alterations in cardiovascular risk factor(CVRF).Objective: To assess changes in lipid profile and other CVRF in transsexual subjects receiving CHT.Materials and methods: Retrospective longitudinal study. We evaluated individuals with gender identity disorder following CHT, assisted in the Gender Identity Unit from 2015 to 2017. Primary endpoint was lipid profile change...