Searchable abstracts of presentations at key conferences in endocrinology
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20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

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ECE 2018, 19 - 22 May 2018; Barcelona, Spain

ePoster Presentations

Interdisciplinary endocrinology

ea0056ep92 | Interdisciplinary endocrinology | ECE2018

FGF21 levels in patients with breast cancer

Sahiner Zeynep , Karaca Anara , Bakar Filiz , Akgul Giray , Ali Gulcelik Mehmet , Gulcelik Nese Ersoz

Aim: FGF-21, is a member of the FGF family that is involved in biological processes such as embryonic development, cellular growth, morphogenesis, tissue repair, tumor growth and invasion, with mitogenic and cellular vital activity activity in the cytogenetic localization of 19q13.33. Breast cancer is the fatal disease most commonly seen in women and increasing in frequency and the relationship between hormones secreted from adipose tissue and some cancers has been shown in re...

ea0056ep93 | Interdisciplinary endocrinology | ECE2018

Pharmacological chaperones for rescue of the mutant AVPR2s

Erdem Beril , Sahin Dilara , Mergen Hatice , Saglar Emel

Using pharmacological chaperones is one of the most common area to rescue trapped proteins from Endoplasmic reticulum (ER) or Golgi apparatus as therapeutic targets in research of some endocrine disorders. Diabetes insipidus is one of these disorders and AVPR2 is seen mostly mutated in hereditary type of the disorder. As proteins go through a journey from ribosome till the place where they function at, AVPR2 also tracks the same way as a G-protein coupled receptor. A mutation ...

ea0056ep94 | Interdisciplinary endocrinology | ECE2018

Tolvaptan; OPC-41 061, Mozavaptan; OPC-31 260, OPC-21 268 as pharmacological chaperones to rescue of mutant AVPR2s

Sahin Dilara , Saglar Emel , Erdem Beril , Mergen Hatice

Nefrojenic Diabetes insipidus is one of the typical conformational disorders result from protein misfolding and degredation or aggregation due to the mutations in AVPR2. The patients of nephrogenic Diabetes insipidus have difficulty in concentrate of urine and because of this, they have polyuria, hypoosmolar urine and hypernatremia in variable levels. To make them relieved, many treatment strategies have been studying and using dDAVP nasally is one of these strategies. Another...

ea0056ep95 | Interdisciplinary endocrinology | ECE2018

A case with autoimmune polyglanduler syndrome type 3A

Batman Adnan , Erol Rumeysa Selvinaz , Ozturk Feyza Yener , Sen Esra Cil , Canat Muhammed Masum , Saygili Emre Sedar , Cakir Sezin Dogan , Basmaz Seda Eren , Yildiz Duygu , Altuntas Yuksel

Introduction: Autoimmune polyendocrine syndromes (APS) are rare endocrinopathies characterized by the coexistence of at least two glandular autoimmune diseases. APS comprise a wide spectrum of autoimmune disorders and are divided into a very rare juvenile (APS type 1) and a more common adult type with (APS 2) or without adrenal failure (APS 3). We present a patient with polyglanduler syndrome type 3a.Case report: A 39-years-old female patient was present...

ea0056ep96 | Interdisciplinary endocrinology | ECE2018

Cardiotoxicity from glycyrrhizic acid inhibition of 11-beta steroid dehydrogenase

Philbey Christopher , Marriott Arran

Ingestion of excessive amounts of liquorice may cause significant electrolyte imbalances due to a mimicking of mineralocorticoid excess. A 70-year-old female attended hospital with palpitations and was found to have hypokalaemia. She was documented to have multiple supraventricular ectopic beats coinciding with her feeling of palpitations, This was precipitated by toxic consumption of liquorice, more than 2 kg in 72 h, to celebrate her 70th birthday. All abnormaliti...

ea0056ep97 | Interdisciplinary endocrinology | ECE2018

Stein leventhal syndrome: a report of two cases

Abdi Amina

Introduction: The polycystic ovary syndrome (PCOS) is the most common endocrine disorder of women. Its clinical manifestations are characterized by infertility, hirsutism and obesity. We report two cases of PCOS but with different signs revelations.Observation 1: 23 year old patient presenting with metabolic syndrome, with dysmenorrhea, after investigation, diagnosis of type two diabetes with PCOS.Observation 2: Patient aged 35 yea...

ea0056ep98 | Interdisciplinary endocrinology | ECE2018

Diabetes mellitus reveals malignant vaterian ampulloma

Abdi Amina

Introduction: Diabetes is a risk factor for pancreatic cancer and recent studies confirm this relationship. We report the case of a patient in whom an inaugural diabetes mellitus revealed a malignant vaterian ampuloma.Observation: A 56-year-old woman with a family history of type 2 diabetes consults for suspicion of type 2 diabetes, polydipsic syndrome, and all-day hyperglycaemia greater than 2 g/dl. During the interrogation, there is a loss of appetite,...

ea0056ep99 | Interdisciplinary endocrinology | ECE2018

Where is the hitch in our interdisciplinary approach? Perceptions of health care providers towards the challenges at diabetes management clinics in Oman

Al-Alawi Kamila , Norberg Margareta , Al Mandhari Ahmed , Johansson Helene

Background: The diabetes management clinics in primary health care centres in Oman aim to provide interdisciplinary diabetes management for their patients. The interdisciplinary management is proved in the literature to have successful outcomes and help the patients to reach their glycemic control fast and safe. Therefore the diabetes management in Oman follows national guidelines, which are based on IDF and AACE guidelines and support the interdisciplinary approach. Despite t...