Endocrine Abstracts

Thyroid cancer is the most common endocrine malignancy giving rise to one of the most indolent solid cancers, but also one of the most lethal. In recent years, systematic studies of the cancer genome, most importantly those derived from The Cancer Genome Altas (TCGA), have catalogued aberrations in the DNA, chromatin, and RNA of the genomes of thousands of tumors relative to matched normal cellular genomes and have analyzed their epigenetic and protein consequences. One unexpe...

Thyroid nodules are common in the population. Ultrasound would detect nodules, in about 25% of the adult and half of the elderly population(>60 years). Only 5% of these nodules are malignant, and 60–70% of the detected benign nodules, remains similar or decrease in size during the long term follow-up. Few nodules, i.e >1.3 cm, would function autonomously and cause thyrotoxicosis. Rarely, large single nodules or multinodulated glands could cause compressive symptom...

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