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20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

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ECE 2018, 19 - 22 May 2018; Barcelona, Spain

Oral Communications

Novel aspects of puberty development and Cushing's disease

ea0056oc12.1 | Novel aspects of puberty development and Cushing's disease | ECE2018

Growth hormone signaling in leptin receptor expressing cells, but not in Kiss1 expressing neurons, regulates the timing of puberty

Bohlen Tabata M , Zampieri Thais T , Furigo Isadora C , Teixeira Pryscila DS , Donato Jose , Frazao Renata

Growth hormone (GH) is an important factor involved in the regulation of multiple biological functions. Although the influence of GH is widespread throughout several organs and tissues, the effects of GH on brain functions, such as those related to reproductive functions, are still elusive. GH deficiency or resistance can be related to late puberty onset, lack of sexual maturation and infertility. In contrast, GH therapy can accelerate puberty onset or be used to increase preg...

ea0056oc12.2 | Novel aspects of puberty development and Cushing's disease | ECE2018

Oligogenicity in Kallmann syndrome - an underestimated phenomenon?

Kaluzna Malgorzata , Budny Bartlomiej , Rabijewski Michal , Debicki Szymon , Trofimiuk-Muldner Malgorzata , Dubiel Agnieszka , Ruchala Marek , Ziemnicka Katarzyna

Isolated hypogonadotropic hypogonadism (IHH) is caused by impaired gonadoliberin (GnRH) gene regulation, synthesis or secretion of GnRH. Genetic factors of more than 50% of the IHH are still unknown. One the most common types of IHH is the Kallmann syndrome (KS) associated with anosmia or hyposmia. In view of technological progress and new possibilities for detecting changes in human genome a comprehensive targeted analysis using next-generation sequencing (NGS) was carried ou...

ea0056oc12.3 | Novel aspects of puberty development and Cushing's disease | ECE2018

Evaluation of genetic predisposition in severe and mild phenotypes of isolated hypogonadotropic hypogonadism

Cangiano Biagio , Duminuco Paolo , Vezzoli Valeria , Guizzardi Fabiana , Persani Luca , Bonomi Marco

Introduction: Isolated hypogonadotropic hypogonadism (IHH) often occurs in the pre-pubertal period but it can also manifest in post-puberal age. Recent position statements and guidelines differentiate between a ‘true’ hypogonadotropic hypogonadism, intended as congenital or acquired organic defect (characterized by frankly pathological total Testoterone values, TTe <3.5 nmol/l), and a ‘false’ or functional hypogonadism, associated to older age and comor...

ea0056oc12.4 | Novel aspects of puberty development and Cushing's disease | ECE2018

Late-night salivary cortisol (LNSC) levels in a Phase III study of long–acting pasireotide in patients with Cushing’s disease (CD)

Newell-Price John , Pivonello Rosario , Tabarin Antoine , Fleseriu Maria , Witek Przemyslaw , Gadelha Monica , Petersenn Stephan , Tauchmanova Libuse , Ravichandran Shoba , Roughton Michael , Lacroix Andre , Biller Beverly MK

Introduction: LNSC has shown high sensitivity and specificity for the initial diagnosis of CD and detection of disease recurrence; however, the use of LNSC to monitor medical treatment of CD is not well established. The results of an exploratory analysis evaluating changes in LNSC in CD patients receiving long-acting pasireotide during a Phase III study (CSOM230G2304; Lacroix et al. Lancet Diabetes Endocrinol 2018) are reported here.Methods: Pat...

ea0056oc12.5 | Novel aspects of puberty development and Cushing's disease | ECE2018

Diabetes mellitus and muscle weakness are independently associated with mortality in patients with Cushing’s syndrome. Data from ERCUSYN

Valassi Elena , Tabarin Antoine , Brue Thierry , Feelders Richard A , Reincke Martin , Neteia-Maier Romana , Toth Miklos , Yaneva Maria , Webb Susan M , Tsagarakis Stylianos , Chanson Philippe , Pfeifer Marija , Droste Michael , Komerdus Irina , Kastelan Darko , Maiter Dominique , Chabre Olivier , Franz Holger , Santos Alicia , Strasburger Christian J , Trainer Peter J , Newell-Price John , Ragnarsson Oskar

Background: Patients with active Cushing’s syndrome (CS) have increased mortality.Aims: Evaluate cause of death in a large cohort of CS patients, and establish factors associated with increased mortality.Methods: We analysed 1514 patients included in the European Registry on Cushing’s syndrome (ERCUSYN): 1022 (68%) had pituitary-dependent CS (PIT-CS), 379 (25%) adrenal-dependent CS (ADR-CS), 71 (5%) had an ectopic source ...