Endocrine Abstracts

Objective: The present study was designed to investigate the impact of insulin treatment on placental maternal and fetal vascular circulation in obese and non-obese women with gestational diabetes mellitus (GDM).Design and methods: One hundred and ninety two women with GDM who gave birth and underwent a placental histopathological examination at Wolfson Medical Center were included in the study: 123 women who were treated with diet (Group 1) and 69 women...

The mammalian target of rapamycin (mTOR) is a serine kinase that couples energy and nutrient abundance to cell growth and is critically involved in the onset and progression of diabetes, cancer and ageing. Placental mTOR is involved in nutrient sensing and transfer to the fetus. Animal models suggest that placental mTOR is upregulated in pregnancies complicated by gestational diabetes (GDM). Our aim was to characterize expression, and cellular localization of mTOR and whether ...

Background: Diabetes is characterized by a prolonged latency between the onset of metabolic abnormalities and the clinical appearance of microvascular disease, consistent with the occurrence of vascular repair in the early stages. Patrolling monocytes (PMo), a subset of circulating monocytes, survey microvessels by crawling on the endothelium; their functional and biosynthetic characteristics suggest they play a role in the protection of the endothelium from vascular stress.</...

Actuality: At present, the role of chronic hyperglycemia in type 1 diabetes mellitus (DM1) in the onset of diabetic encephalopathy has been proven. At the same time, violations in the metabolic composition of brain cells were detected in persons with DM1, estimated with the proton magnetic resonance spectroscopy (1H-MRS). However, the relationship between the results of these studies has not yet been studied.The aim: To reveal the relationship...

Background: Cardiovascular disease (CVD) is the leading cause of death in persons with type 1 diabetes (T1DM). However, there are no CVD-risk prediction models for this population in widespread use and those developed from general population and type 2 diabetes have been shown to underestimate CVD-risk in T1DM. Recently, the Steno Type 1 Risk Engine (ST1RE) was developed for predicting CVD in a cohort of T1DM persons without clinical CVD. We investigate the relationship betwee...