Endocrine Abstracts

Type 2 diabetes (T2DM) patients are at high risk for vascular complications. Some of them have even a higher risk during metformin therapy, as we have recently shown by associations of polymorphisms in the Oct1 gene with a therapy-dependent increased risk of cardiovascular death. In this study, we investigated whether Oct1 gene variants were associated with cardiovascular characteristics such as pulse wave velocity (PWV), echocardiographic parameters and intima/media thickness...

Introduction and aim: Leptin is a hormone that mainly expressed and secreted in adipose tissues and has a number of important effects on regulation of body weight, energy expenditure, and thermogenesis. High intake of n-3 polyunsaturated fatty acids (PUFA) promotes reduced plasma concentration of triacylglycerol, glycerol, and free fatty acids, as well as metabolism of the epididymis. The aim of current study was to examine the association of n-3PUFA on leptin gene expression ...

Introduction: This study aimed to examine whether altered Heart Rate Variability (HRV) could predict the risk of development of metabolic syndrome (MetSD) in Asians.Methods: We investigated health checkup records of 33 752 adults aged 20–65 years old who did health checkups and HRV measurement between April 2011 and June 2014 at Kangbuk Samsung Hospital, without MetSD, anemia, thyroid disease, malignancy, and heart disease. A 3-minute HRV recording ...

Background: The recently discovered myokin Irisin, a peptide originated by a proteolytic cleavage of the transmembrane protein fibronectin type III domain containing 5 (FNDC5) whose expression is induced by exercise and/or by increasing peroxisome proliferator-activated receptor (PPAR)-γ co-activator 1α (PGC-1α), has been considered a prognostic factor in Chronic Ischemic Cardiomyopathy and Acute Heart Failure. Nevertheless, no data are available on Irisin level...

Idiopathic pulmonary fibrosis (IPF) is an excessive accumulation of fibrous filaments in the extracellular matrix (ECM), in response to an inflammatory reaction that disrupts normal lung architecture and physiology. Collagen is the most abundant fibrous protein in the ECM. The GLP-1 receptor is highly expressed on lung tissue, where his activation plays an essential role in the synthesis and secretion of surfactant proteins. The objective of this study was to elucidate the eff...

Introduction: Turner Syndrome (TS) is associated with cardiovascular anomalies and account for a threefold higher mortality in these women. The most common findings are congenital malformations of the heart (CMH), aortic dissection, valvular heart disease (VHD), hypertension and ischemic heart disease. It has been suggested that the ocurrence of cardiovascular disease in TS women is related to their karyotype and possibly to growth hormone (GH) treatment. Our study aimed to as...

Introduction: Differentiation between familial chylomicronemia syndrome (FCS), a rare hypertriglyceridemia, and severe hypertriglyceridemia (sHTG; non-FCS) is challenging due to overlap in triglyceride (TG) levels and symptomology but important in disease management. Clinical characteristics that allow for reliable differentiation may exist in the presenting clinical features and primary diagnostic testing. The objective of this analysis was to assess whether readily obtainabl...

Importance: Few studies have compared mid-term results of laparoscopic Roux-en-Y gastric bypass versus laparoscopic sleeve gastrectomy and none have focussed on lipid profile.Objectives: The main objective of this study was to compare laparoscopic Roux-en-Y gastric bypass versus laparoscopic sleeve gastrectomy with respect to 5-year remission rate of the different lipid disturbances. Secondary outcomes included relapse, late remission and incidence rates...