Endocrine Abstracts

In this study, human neural stem cells (hNSCs) were used to cancer treatment strategy for anaplastic thyroid cancer (ATC) owing to their tumor tropic properties. Cytosine deaminase (CD) can convert a prodrug, 5-fluorocytosine (5-FC), to drug, 5-fluorouracil (5-FU), which inhibits tumor growth through DNA synthesis inhibition. Also, IFN-β expression suppresses tumor growth by apoptotic process. Then, we investigated tumor inhibition effect of hNSCs in vitro and <e...

Background and objective: The AJCC-TNM system is optimized to predict survival in patients with cancer. Since January 2018, the new eighth edition of this staging system will be used to classify patients diagnosed of differentiated thyroid carcinoma (DTC). This study aims to compare the seventh and eighth editions of the AJCC-TNM system in a Spanish Cohort of DTC.Patients and Methods: The Cadit-CAM study was designed to evaluate characteristics of patien...

Introduction: CHEK2 gene is one of the genes in the DNA repair complex. Dysfunction of genes in this complex leads to genomic instability and is regarded as a cause of tumorigenesis. CHEK2 mutations spectrum was assessed in many populations, including polish one. The most common are mutations truncating CHEK2 protein (1100delC, IVS2+1G>A, del5395) and a missense I157T CHEK2 mutation. Literature data indicate that mutations truncating CHEK2 protein lead to a five-fold incre...

Aim: To assess the accuracy of the TBSRTC in verification of thyroid carcinoma in the region of Moscow county.Material and methods: A retrospective study of data from electronic medical notes of 1,675 patients who underwent fine needle aspiration biopsy of nodular thyroid glands in 2016. The cytological conclusion was evaluated in accordance with the TBSRTC. In cases of surgical treatment (thyroidectomy or hemithyroidectomy) the cytological diagnosis was...

Undifferentiated/Anaplastic thyroid carcinoma (ATC) is one of the most aggressive and deadly cancers. It is characterized by loss of thyroid expression markers and no response to conventional treatments. ATC incidence is low representing <2% of all thyroid carcinomas. This, together with its high mortality, makes difficult the development of clinical trials. In our previous works, we have developed a system to culture patient-derived thyroid cancer cells (h7H) that is a go...

Background: Differentiated Thyroid Carcinomas (DTC) represent more than 90% of thyroid tumors with good prognosis and long survival. Currently, patients with intermediate/high risk nodule as assessed by cytological staging may undergo surgery. According to ATA 2017 guidelines, all patients presenting thyroid nodules with suspicious ultrasound features (hypoechoic pattern, irregular margins, microcalcifications, etc.) and cytopathology TIR3B, TIR4 or TIR5 according to 2014-SIAP...

Introduction: Thyroid nodules may be detected in up to 67% of the adult population and constitute big diagnostic challenge. Presurgical differentiation of follicular lesions between follicular adenoma (FA) and follicular thyroid carcinoma (FTC) is particularly difficult. Commercially available gene panels cover only a few, selected mutations to help in discrimination between FA and FTC. The aim of this study was to comprehensively assess the genetic background of thyroid folli...

Introduction: The TNM classification of the American Joint Committee on Cancer (AJCC) and the Union for International Cancer Control (UICC) is the most widely used thyroid cancer staging system. The 8th edition was published in 2016 and introduced modifications to the N0 classification. Histological analysis is no longer necessary for patients to be classified as N0, as long as there is no evidence of lymph node (LN) metastasis in the preoperative imaging tests or clinical eva...

Introduction: In 2014, the British Thyroid Association (BTA) issued guidance on thyroid cancer and introduced a new scoring system for thyroid nodules based on their sonographic appearances (U1-U5). The guidelines specified that nodules with indeterminate or suspicious appearances (U3-U5) should undergo fine needle aspiration (FNA) assessment. This study audits the implementation of the guidelines in our hospital and evaluates any changes in the management of thyroid nodules.<...

Context: Risk stratification for persistent disease is an important step in pediatric differentiated thyroid cancer (DTC) management. The dynamic risk stratification (DRS) is a well validated system for adults, but not yet for children and adolescents.Objective: To evaluate DRS performance and other prognostic factors in pediatric DTC.Design: Cohort study.Setting: Four DTC referral centers at tertiary teachin...