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20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

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ECE 2018, 19 - 22 May 2018; Barcelona, Spain

ea0056p71 | Adrenal medulla | ECE2018

Imaging characteristics of pheochromocytomas

Sakka Imen , Oueslati Ibtissem , Chihaoui Melika , Khessairi Nadia , Rached Amal , Yazidi Meriem , Melki Amel , Slimane Hedia

Introduction: Pheochromocytomas are uncommon neuroendocrine tumors arising from chromaffin cells of the adrenal medulla. The aim of our study was to assess imaging characteristics of pheochromocytomas.Methods: The study was a retrospective analysis of 23 patients with pheochromocytomas. All participants had a computed tomography scan (CT). Several clinical and radiologic features were statistically analysed.Results: The Mean age wa...

ea0056p72 | Adrenal medulla | ECE2018

Genetics in pheochromocytoma and paraganglioma: a case series

Gonzalez Lazaro Paloma , Contreras Pacual Cristina , Silva Fernandez Julia , Torres Arroyo Belvis , Javier Gomez Alfonso Francisco , Del Val Zaballos Florentino , Gomez Garcia Ines , Garcia Manzanares Alvaro

Introduction: In most patients with familial history of pheochromocytoma/paraganglioma, leads in the majorty of cases to a postive genetic testing for mutations, and what’s more in those patients with no familial antecedents, about 10–25% carry a mutation in one related gene. In these cases other aspects like, bilaterality, multiplicity or location must be taken into account.Objective: The objective of the study was to discuss the importance of...

ea0056p73 | Adrenal medulla | ECE2018

Analysis of a pheochromocytoma case series over 12 years: a specialty hospital experience

Cayon-Blanco Manuel , Naranjo-Velasco Virginia , Garcia-Figueras-Mateos Carolina , Garcia-Garcia-Doncel Lourdes , Marquez-Pardo Rosa , Gloria Baena-Nieto M. , Mateo-Vallejo Francisco

Introduction: Pheochromocytomas are the most common tumours of adrenal medullary origin. The aim of this study is to describe the clinical manifestations, biochemical profile, preoperative pharmacological approach and hemodinamic outcomes in a series of patients with histologically proven pheochromocytoma treated in our center over 12 years.Methods/design: Descriptive analysis including patients diagnosed with pheochromocytoma after histological examinat...

ea0056p74 | Adrenal medulla | ECE2018

Laparoscopic surgery for pheochromocytoma: perioperative outcomes

Cayon-Blanco Manuel , Naranjo-Velasco Virginia , Garcia-Figueras-Mateos Carolina , Garcia-Garcia-Doncel Lourdes , Marquez-Pardo Rosa , Gloria Baena-Nieto M. , Mateo-Vallejo Francisco

Introduction: Laparoscopic adrenalectomy is a promising alternative to open surgery although concerns exist in regard to laparoscopic treatment of pheocromocytoma. This report aims to describe the outcomes of laparoscopic resection for pheocromocytoma focusing particularly on intraoperative hemodynamic stability and postoperative outcomes.Methods/design: Descriptive analysis including patients who underwent laparoscopic surgery for unilateral pheochromoc...

ea0056p75 | Adrenal medulla | ECE2018

Malignant pheochromocytoma discovered upon consultation for painful erections

Garcia-Garcia-Doncel Lourdes , Marquez-Pardo Rosa , Cayon-Blanco Manuel , Lopez-Velasco Rosario , Baena-Nieto Gloria

Introduction: Pheochromocytomas (PCCs) and paragangliomas (PGL) are rare but unique tumors. Only 10% of PCCs are malignant, defined by metastases. Metastases can be seen at diagnosis of the primary tumor or develop even 20 years later. Approximately half of patients with metastatic PCC/PGL have inherited SDHB mutations.Case report: A 45-year-old man was referred to Urology for curvature of the penis and painful erections. Among his medical background hig...

ea0056p76 | Adrenal medulla | ECE2018

Can patients with a large sporadic pheochromocytoma and very high norepinephrine secretion be normotensive? Yes, they can!

Dolores Perez-Ramada Maria , Ramos-Gomez Isabel , Fernandez-Trujillo-Comenge Paula , Delia Santana-Suarez Ana , Esteban Nivelo-Rivadeneira Manuel , Kuzior Agnieszka , Acosta-Calero Carmen , Arnas-Leon Claudia , Quintana-Arroyo Sara , Javier Martinez-Martin Francisco

Introduction: Classically, hypertension (sustained or paroxysmal) is described in > 98% of diagnosed pheochromocytomas. Nowadays the systematic workup of adrenal incidentalomas has made uncovering normotensive pheochromocytomas no longer exceptional. However, normotensive pheochromocytomas have a catecholamine secretion characteristically lower than hypertensive pheochromocytomas. It must be emphasized that the perioperative hemodynamic instability is comparable in hyperte...

ea0056p77 | Adrenal medulla | ECE2018

Pheochromocytoma revelation modalities: about 23 cases

Zahra Zaher Fatima , Okoumou Moko Aymande , Doubi Sana , Rafi Sana , Elmghari Ghizlane , Elansari Nawal

Introduction: Pheochromocytoma is an endocrine tumor developed in the chromaffin cells of the adrenal medulla and excessively secreting catecholamines in varying amounts and types. It represents a rare tumor, often benign, but serious considering its mainly cardiovascular complications. The purpose of our study is to specify the revelation methods of pheochromocytomas in our population.Patients and methods: Our study has included 23 cases of pheochromocy...

ea0056p78 | Adrenal medulla | ECE2018

When the large tumor is not the first intention for removal-concomitant discovery of left adrenal pheochromocytoma and a possible retroperitoneal plexiform neurofibroma in a case of familial neurofibromatosis type 1- case report

Costache Outas Mariana , Valcu Alice , Lamasz Andru , Giulea Cosmin

Neurofibromatosis type 1 (NF1) is a rare autosomal dominant disorder characterized by the development of multiple benign tumors of the nerves and the skin (neurofibromas) and areas of abnormal increased and decreased coloration of the skin. Pheochromocytoma develops in 0.1–5.7% of NF1 patients and plexiform neurofibroma in 30% of NF1 patients. We present a case of a 38-year-old female, without relevant personal, with a familial phenotype suggestive for NF1, evaluated for ...

ea0056p79 | Adrenal medulla | ECE2018

Why is it important to screen secondary endocrine hypertension in resistant cases? Lessons from a patient with progressive renal failure

Esteban Nivelo-Rivadeneira Manuel , Ramos-Gomez Isabel , Dolores Perez-Ramada Maria , Delia Santana-Suarez Ana , Kuzior Agnieszka , Fernandez-Trujillo-Comenge Paula , Acosta-Calero Carmen , Arnas-Leon Claudia , Quintana-Arroyo Sara , Javier Martinez-Martin Francisco

Introduction: Even though most hypertensive patients have essential hypertension, in the resistant cases the prevalence of secondary hypertension is much higher; therefore its screening should be mandatory. Resistant hypertension usually causes a progressive decline of renal function if blood pressure is not adequately controlled. Such decline is often irreversible; however a timely diagnosis leading to a resolutive treatment can alleviate or even revert the progression of the...

ea0056p80 | Adrenal medulla | ECE2018

Association of pheochromocytoma and neurofibrematosis type1: about 4 cases

Fennoun Halima , El Aziz Siham , Mjabber Amal , Chadli Asma

Introduction: Pheochromocytoma is rarely associated with neurofibromatosis type 1 (NF1). We report 4 observations of hospitalized patients in theIbn Rochd University Hospital endocrinology department in Casablanca.Observation 1: A 52-year-old male patient was admitted for NF1-associated malignant pheochromocytomawith paroxysmal hypertension, Menard triad, elevated methoxylated urinary derivatives (DMU), and 11 * 8 cm right adrenal mass with hepatic metas...

ea0056p81 | Adrenal medulla | ECE2018

A retrospective audit on the peri-operative management of phaeochromocytomas: “Phenoxybenzamine or Doxazosin”?

Ni Lee Yun , Casey Edel , Baig Mirza Asfand , Wickramsinghe Sasala , Jones Stuart , Nagy Zoltan , Syed Imran , Kelkar Anand , Stojanovic Nemanja , Pittathankal Antony , Tanday Raj , Nikookam Khash

Phaeochromocytomas are rare catecholamine secreting tumours with an incidence of 1:4500–1:1700 in the United States. Doxazosin and Phenoxybenzamine are alpha-1 selective and non-selective alpha blockers respectively which are commonly used to treat this condition peri-operatively. There are no randomized controlled studies comparing the effectiveness of these two medications. However, there are retrospective studies comparing these two medications; some favouring alpha-1 ...