Endocrine Abstracts

Introduction: Cushing’s syndrome adrenal’s origin coul’d be an adenoma, an unilateral carcinoma and rarely a micronodular or macronodular hyperplasia. We report the cases of two patients followed for macronodular adrenal hyperplasia hospitalized in the Ibn Rochd University Hospital, endocrinology department in Casablanca.

Case 1: A 60-year-old patient with independent ACTH Cushing Syndrome with clinical and biological signs of hypercorticism with collapsed ACTH and unilateral adrenal mass at CT. Treatment consisted of an adrenalectomy with a good evolution. The anatomopathological examination objectified a macro-nodular adrenal hyperplasia.

Case 2: A 48-year-old female presented an independent ACTH Cushing Syndrome, discovered with clinical and biological signs, with normal ACTH, and a right adrenal nodule on CT. Patient underwent right-sided adrenalectomy with good progression. Histopathological examination showed macro-nodular adrenal hyperplasia.

Discussion and conclusion: Unilateral adrenal hyperplasia is a rare etiology of ACTH-independent Cushing’s syndrome, often taken for adrenal adenoma on CT. This hence the value of histopathological examination for diagnosis confirmation.