Results: Main clinical, analytical and polygraphic data: 58.1±6.4 years, body mass index 32.4±5.4 kg/m2, 70.4% female, HbA1c 8.0±1.9%, AIH 27.4 events/hour (in the range of severe sleep apnea and hypoapnea index), and CT90% 32.9%. Nocturnal concentration of urine total metanephrines were higher than diurnal levels (226±12 vs 98±13 μg/l; P=0.085). In addition, its nocturnal concentration was significantly associated, in a positive way, with both the AIH and the CT90; however, this association disappeared when the diurnal concentration was evaluated. Furthermore, nocturnal concentration was also associated with a decrease in resting parasympathetic tone. In the multivariate analysis, the concentration of urine metanephrines at night independently predicted CT90 (P=0.016).
Conclusion: We suggest that the increased sympathetic activity previously described in patients with T2D is mediated through the deleterious effect of diabetes in nocturnal breathing. In addition, sympathetic activity is associated with disorders of autonomic tone at resting, suggesting a new pathological pathway between T2D and cardiovascular risk.
19 - 22 May 2018
European Society of Endocrinology