Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2018) 56 P233 | DOI: 10.1530/endoabs.56.P233

ECE2018 Poster Presentations: Calcium and Bone Calcium & Vitamin D metabolism (59 abstracts)

Association of vitamin D status with pulmonary function: potential mediation by physical function and inflammation

Rachida Rafiq 1 , Natasja van Schoor 1 , Paul Lips 1 , Martin den Heijer 1 , Martijn Spruit 2 & Renate de Jongh 1


1VU University Medical Center, Amsterdam, Netherlands; 2Ciro, Horn, Netherlands.


Background: Several studies have reported an association between serum 25-hydroxyvitamin D (25(OH)D) concentrations and pulmonary function in the general population. However, results remain conflicting. In addition, the underlying mechanisms by which vitamin D affects pulmonary function are unknown.

Objective: To assess the relationship of vitamin D status with pulmonary function and whether this relationship is mediated by physical function and/or inflammation. We will also examine potential effect modification of sex and smoking in this relationship.

Methods: We analyzed data from the Longitudinal Aging Study Amsterdam (LASA), an ongoing population-based, prospective cohort study in the Netherlands. Data for this study were obtained from the third cohort (2012/2013). For this study we used data of 551 participants aged between 55 and 65 years, with complete data on serum 25-hydroxyvitamin D (25(OH)D, CRP, IL-6 and pulmonary function tests (Forced Expiratory Volume in one second (FEV1) and Forced Vital Capacity (FVC). In the regression analyses we corrected for age, sex, BMI, serum creatinine, smoking status, alcohol consumption, educational level, physical activity and season of blood collection. In addition, effect modification of sex and smoking, and mediation by physical performance, IL-6 and CRP was tested.

Results: In men, serum 25(OH)D was associated with pulmonary function: 10 nmol/L higher serum 25(OH)D was associated with 1.01% predicted higher FEV1 (95%CI: 0.03 to 1.98) and 1.02% predicted higher FVC (95%CI: 0.26 to 1.77). In women no assocation between serum 25(OH)D and FEV1 (B(95%CI):-0.19 (−1.17 to 0.78)) and FVC (0.12 (−0.74 to 0.97)) was found. No effect modification by smoking was found. Serum 25(OH)D had an indirect effect on FEV1 through physical performance in women. No mediation effect of physical performance in the relationship between serum 25(OH)D and FVC was seen. In addition, CRP and IL-6 were no mediators in the relationships between serum 25(OH)D and FEV1 and FVC.

Conclusion: Higher serum vitamin D concentrations were associated with better pulmonary function in men, but not in women. Further studies are needed to elucidate potential mechanisms underlying the difference between men and women.

Volume 56

20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

European Society of Endocrinology 

Browse other volumes

Article tools

My recent searches

No recent searches.