Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2018) 56 P536 | DOI: 10.1530/endoabs.56.P536

ECE2018 Poster Presentations: Diabetes, Obesity and Metabolism Obesity (78 abstracts)

The effect of n-3 PUFA on lipid profile, inflammation and insulin resistance

Mona Nourbakhsh 1, , Mitra Nourbakhsh 3 & Maryam Razzaghy Azar 1,


1Hazrat Aliasghar Children’s Hospital, Iran University of Medical Sciences, Tehran, Iran, Republic of Islamic; 2Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran, Republic of Islamic; 3Department of Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran, Republic of Islamic.


Insulin resistance, lipid imbalance and inflammatory process have deleterious effect on cardiovascular system. Omega-3 polyunsaturated fatty acids (n-3 PUFA) (Docosahexaenoic acid [DHA] and Eicosapentaenoic acid [EPA]) are lipids that have beneficial effects. Our objective was to study the effects of n-3PUFA on anthropometric characteristics, inflammation, lipid profile and insulin resistance of the children with obesity.

Materials and methods: Thirty obese children aged 8–18 year with body mass index (BMI) >95% for their age and gender were enrolled into the study. After clinical evaluation and sample collection, patients were treated with 1250 mg of n-3 PUFA containing EPA 425 mg and DHA 325 mg, once a day for three months. Anthropometric characteristics were measured and BMI was calculated. Fasting blood glucose, insulin, CRP and lipids were measured in fasting blood samples before and after intervention. P<0.05 was considered significant.

Results: Treatment with n-3 PUFA did not have any significant effect on anthropometric characteristics including BMI, waist and hip circumference and waist to hip circumference ratio. Serum CRP level changed from 2.85±1.65 mg/dl to 1.3±1.03 mg/dl which significantly showed decreased inflammation in response to n-3 PUFA administration (P<0.001). In lipid profile, blood triglyceride was changed from 117.5±70.4 mg/dl to 91.8±42.2 (P=0.01) and LDL-C from 91.3±20.6 to 81.8±20.6 (P<0.001). HDL-C was 42.76±9.2 and reached to 47.14±9.6 (P=0.05). Homeostasis model assessment (insulin resistance) (HOMA-IR) changed from 5.14±3.1 to 4.11±2.5 (P=0.04).

Conclusion: Short term administration of omega 3 fatty acids decreased insulin resistance and inflammation, changed lipid profile in better conditions but did not change anthropometric characteristics of obese children in short duration of study.

Volume 56

20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

European Society of Endocrinology 

Browse other volumes

Article tools

My recent searches

No recent searches.