Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2018) 56 P551 | DOI: 10.1530/endoabs.56.P551

ECE2018 Poster Presentations: Diabetes, Obesity and Metabolism Obesity (78 abstracts)

Influence of lifestyle modification on leptin and insulin resistance to prevent type 2 diabetes mellitus development

Elena Shishko , Tatyana Mokhort & Elena Mokhort


Belarusian State Medical University, Minsk, Belarus.


The aim of the present study was to determine the change of fasting serum leptin and insulin levels and insulin resistance in patients with risk factors of diabetes mellitus of type 2 (DM 2) including impaired glucose tolerance/impaired fasting glucose (IGT/IFG).

Material and methods: The study included 100 patients (32 men, 68 female) 25–65 years old at risk factors of DM 2. All patients received recommendations on a balanced diet and physical activity. The average fasting plasma glucose (FPG), HbA1c, fasting serum leptin was detected by sensitive ELISA.

Results: During 18 months our study 56 patients carried out this recommendations (research group) and 44 patients did not (control group). Patients of the research group demonstrated mean reduction of body mass index (−2.6±0.4 kg/m2) and persons of the control group had significant increase of these parameters (P<0.05). Among subjects with IGT/IFG at baseline, glucose levels normalized in 56.0% of patients from the research group and 4.5% in control group (P<0.001). FPG and HbA1c in research group decreased from 11.9±4.3 to 9.6±4.5 μU/ml and from 6.4±0.3 to 6.1±0.3% accordingly (P<0.05). In control group the specified parameters had increased significantly (P<0.01). The serum leptin median in research group was decreased from 34.7 to 26.4 ng/ml (−23.9%, P<0.001) and increased in control group (+17.9%, P<0.01). The risk reduction of DM 2 development among patients of the research group was 48.0% compared to the control group.

Conclusion: Thereby, lifestyle modification can prevent the development of DM 2 in subjects with risk factors by reduction leptin.

Volume 56

20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

European Society of Endocrinology 

Browse other volumes

Article tools

My recent searches

No recent searches.