ECE2018 Poster Presentations: Interdisciplinary Endocrinology Cardiovascular Endocrinology and Lipid Metabolism (6 abstracts)
Impact of the metabolic syndrome on the renal function after partial nephrectomy for nonmetastatic localized renal cell carcinoma
Kays Chaker , Ahmed Sellami , Yassine Ouanes , Mohamed Ali Ben Chehida , Mohamed Ali Essid , Mokhtar Bibi , Karem Abid , Sami Ben Rhouma & Yassine Nouira
Urology Department, La Rabta Hospital, Tunis, Tunisia.
Introduction and objectives: The most important risk factors of chronic kidney disease (CKD) are diabetes and hypertension. In addition, obesity and metabolic syndrome (MetS) are independent predictive factors of CKD. The objective of our study was to investigate if MetS affects renal function of patients who underwent partial nephrectomy for localized renal cell carcinoma (RCC).
Patients and methods: 50 cases of T1N0M0 RCC patients who underwent partial nephrectomy between 2002 and 2016 at our institution were reviewed retrospectively. Patient’s history and clinicopathological characteristics of RCC were compared with and without MetS status. Estimated glomerular filtration (eGFR) was calculated using the Modification of Diet in Renal Disease (MDRD) formula. We evaluated preoperative and postoperative eGFR, as well as overall survival (OS) with MetS status. Data was analyzed using two-sample Student’s t-tests and the Pearson’s χ2-test (categorical variables). Survival analysis was estimated using kaplan-Meier method comparing with MetS status.
Results: Gender and age had not a statistically-significant impact in patients with and without MetS. (P>0.05). Clinicopathological characteristics of RCC were not different in both groups (P>0.05). In MetS(+), preoperative and postoperative eGFR were lower than MetS(−) (70.2±25.44 vs 78.6±26.17; 57.3±24.6 vs 71.6±28.1). The difference between preoperative and postoperative eGFR was statistically different between the two groups (P=0.04).Overall survival stratified with MetS status wasn’t statistically different (P>0.05).
Conclusion: Although preoperative and postoperative eGFR are lower in MetS(+) and the changes of eGFR are different between the two groups after partial nephrectomy, MetSdid does not affect overall survival.
Volume 56
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more