ECE2018 Poster Presentations: Interdisciplinary Endocrinology Thyroid (non-cancer) (2 abstracts)
Role of Pro-inflammatory biomarkers in Hashimoto’s thyroiditis: A prospective study
B Ramesh 1 , B Rajesh 1 , B Rajkiran Reddy 2 , G Gayathri 1 , M Venkateshwara Reddy 1 , D Vighnesh 1 , B Chakrapani 3 & PRK Bhargav 4
1VMC, Kurnool, India; 2SMART Sunshine Hospital, Hyderabad, India; 3Neuro Hospital, Nizamabad, India; 4Endocare Hospital, Vijayawada, India.
Introduction: Hashimoto’s thyroiditis (HT) is one of the commonest organ specific autoimmune thyroid disease. Though it is mostly treated medically, certain goitrous forms require surgical thyroidectomy for various indications. Autoimmunity has been implicated as one of the main cause of HT. In this context, we set out study the role of Pro- inflammatory cytokines in HT.
Material and methods: This prospective case-control study was conducted on surgically managed HT patients. Institutional ethical committee approval was obtained. Diagnosis of HT was based on thyroid function tests, anti-TPO antibody titer, radionuclide scanning and histopathology. Exclusion criteria were subjects any systemic or chronic inflammatory disease or any medication which interferes with the normal function of the hypothalamic-pituitary-gonadal axis. Serum samples were collected from 25 HT subjects and 25 age matched healthy controls. Interleukin-6 (IL-6), Tumour necrosis factor-alpha (TNF-α) and high sensitive C reactive protein (hsCRP), Leptin levels were measured in all serum samples. Statistical analysis was performed by one way ANOVA with Dunnet’s test and Pearson correlation tests.
Results: The mean hSCRP level in GD and controls were 14.7±2.9 mg/mL and 6.5±1.7 mg/mL respectively. The mean TNF-α level, IL-6 level and Leptin levels were 234±26 pg/mL, 12.6±4.5 pg/mL and 32±4.9 ng/mL respectively. There was statistically significant difference of all the pro-inflammatory cytokines compared to controls (P value < 0.05).
Conclusions: This study shows raised titers of pro-inflammatory markers – IL-6, TNF-α and hsCRP, leptin correlated with HT suggesting a contributory role. But, the exact immuno-modulatory role and pathogenetic mechanism needs active research.
Keywords: Hashimoto’s thyroiditis, Tumour necrosis factor, Interleukin-6, Goiter, Auto-immunity, Leptin
Volume 56
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Endocrine Abstracts
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