Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2018) 59 EP107 | DOI: 10.1530/endoabs.59.EP107

SFEBES2018 ePoster Presentations Thyroid (24 abstracts)

Neonatal thyrotoxicosis caused by persistently high levels of thyroid stimulating antibodies in autoimmune hypothyroidism

Daniel Marr , Kamal Abouglila & Suzanne El-Kholy


Endocrine Department, University Hospital of North Durham, Durham, UK.


Neonatal immune hyperthyroidism is a rare but potentially fatal condition. It occurs in 1–5% of infants born to women with Graves’ disease (GD). We present a case of neonatal thyrotoxicosis due to maternal hypothyroidism secondary to radioactive iodine treatment for Graves’ disease. A new-born female at 13-days of age was readmitted due to maternal concerns. She noted the baby to be jittery, unsettled, tachycardic and tachypnoeic. The infant was born via a spontaneous vaginal delivery at 38+1 weeks’ gestation to a gravida 1, para 1 mother. The infant’s birthweight was 2750g. The mother was taking thyroxine. She was commenced on intravenous antibiotics for presumed sepsis, however despite normal inflammatory markers and cultures, the infant continued to deteriorate. The tachycardia persisted and she started vomiting so was admitted to Special Care. Thyroid function tests were done which confirmed neonatal hyperthyroidism (TSH <0.05 T4 124) due to high level of TBII (Thyrotropin binding Inhibitory Immunoglobulin) of 6.2. The mother had positive TBII of 17.8 IU/L at 32 weeks gestation during pregnancy. The baby was then commenced on carbimazole and propranolol. Clinically the symptoms resolved and as her bloods (including TFT) were improving, she was discharged on 13/4/18 with a weaning dose of carbimazole. Last TFTs were normal with TSH 2.1, T3 5.8 and T4 11. She is being regularly followed up as an outpatient and she has been fully weaned off her carbimazole.

Conclusion: This case illustrates the importance of measuring TBII during prenatal care and follow up in order to help early diagnosis of neonatal hyperthyroidism and improve neonatal outcomes. Both Obstetricians and paediatricians need to be aware of the importance of a high TBII at the end of pregnancy to predict the risk of neonatal hypothyroidism in autoimmune hypothyroidism secondary to radioiodine treatment.

Volume 59

Society for Endocrinology BES 2018

Glasgow, UK
19 Nov 2018 - 21 Nov 2018

Society for Endocrinology 

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