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Endocrine Abstracts (2018) 59 APW2.1 | DOI: 10.1530/endoabs.59.APW2.1

1Imperial College London, London, UK; 2University of Würzburg, Würzburg, Germany; 3UK.


Bariatric surgery, in particular, Roux-en-Y gastric bypass (RYGB), is the most effective treatment for morbid obesity. The restricted gastric capacity and reduced absorption of nutrients cannot account for all the metabolic benefit we observe post-operation. Therefore, we applied metabolic and microbial profiling approach to investigate the potential mechanisms of RYGB surgery. Metabolic profiling strategy is widely applied in the discovery and development of metabolic biomarkers of disease and therapeutic intervention in personalized healthcare, as well as for characterizing host-gut microbial metabolic interactions. We carried out RYGB surgery in a range of rodent models and applied metabolic, microbial and microRNA profiling to study systemic responses of the body to RYGB surgery. All these rodent models showed a significant weight loss in the RYGB-operated animals and significant increases in the gut hormones, e.g. PYY and GLP-1. Consistent changes in tricarboxylic acid cycle intermediates and host-microbial co-metabolism were also found and these changes are independent of the reduced food intake or weight loss post-operatively. The faecal bacterial composition also shifted from Firmicute-dominant to Proteobacteria-dominant community. We also observed that 14 circulating microRNAs differentially expressed post RYGB, which could be associated with increased energy expenditure post-surgery. In human cohorts, we also observed significant changes in host-microbial co-metabolites and decreased branched-chain amino acids in serum of the RYGB patients. Our studies showed that RYGB surgery induced changes in both local and global metabolic activities. These findings aid our understanding of the metabolic phenotype of bariatric procedures and can facilitate development of alternative treatments for obesity-related diseases.

Volume 59

Society for Endocrinology BES 2018

Glasgow, UK
19 Nov 2018 - 21 Nov 2018

Society for Endocrinology 

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