SFEBES2018 Poster Presentations Thyroid (27 abstracts)
Characterization of thyroid nodules in acromegalic patients
Raluca Trifanescu 1, , Simona Galoiu 1, , Dan Niculescu 1, , Ionela Baciu 1, , Cristina Capatina 1, , Serban Radian 1, & Catalina Poiana 1,
1‘Carol Davila’ University of Medicine and Pharmacy, Bucharest, Romania; 2‘C.I.Parhon’ National Institute of Endocrinology, Bucharest, Romania.
Background: Thyroid nodules were reported with high prevalence in acromegalic patients.
Patients and methods: 63 acromegalic patients (16 males and 47 females), aged at diagnosis 43.6±12.7 years were retrospectively reviewed. Median duration of acromegaly was 8 years. 25 patients were residents in iodine deficient areas. GH, IGF1, TSH, FT4 were measured by chemiluminescence (Liaison). Thyroid ultrasound was performed. In suspected nodules, pathological examination (either fine needle aspiration with cytology exam or pathology exam after thyroidectomy) was performed.
Results: Median thyroid volume was 20.72 ml. Thyroid nodules were present in 52 patients (82.5%). Multiple thyroid nodules were found in 45 out of 52 cases (86.5%). Toxic multinodular goiter was prezent in 5 patients (7.9%). Average maximum diameter of dominant nodule was 1.7±1.3 cm. Thyroid differentiated cancer was diagnosed in 6 patients (9.5%). Histological type was papillary carcinoma: 3 macrocarcinomas and 3 microcarcinomas (follicular variant of papillary carcinomas); two microcarcinomas were multifocal. Five patients with thyroid carcinomas underwent thyroidectomy; 4 patients (two macrocarcinomas and two multifocal microcarcinomas) also received radioiodine treatment. Thyroid surgery is pending in one patient. Autoimmune thyroiditis was present in 4 patients (6.3%).
Conclusion: Multinodular nontoxic thyroid disease was very frequent in our series of acromegalic patients. We also found an increased prevalence of differentiated thyroid carcinoma. Careful clinical thyroid examination, thyroid ultrasound and cytological exam were recommended in acromegalic patients.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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