Endocrine Abstracts

In recent years the genomic landscape of pancreatic neuroendocrine tumours (PNETs) has been elucidated through unbiased exome, whole genome and ingrated genomic analyses. Most commonly mutations in the epigenetic machinery occur – ATRX / DAXX / Menin affecting 40–45% of cases. Alongside this, mutations occur less frequently in the mTOR pathway and DNA repair genes. It has also been determined that 17% of cases have an underlying germline mutation. Recent developments in integrated genomic analysis and molecular profiling of PNETs will be presented with discussion of how these findings might be introduced in to clinical practice.