Endocrine Abstracts

Objective: To evaluate the chance of developing new cases of Type 2 diabetes mellitus (DM) in obese people in the population sample of the city of Novosibirsk aged 45–69 years.

Materials and methods: The analysis included 2464 people, including 586 (23.7%) men and 1878 (76.2%) women without DM. This sample was formed from the base of the international project HAPIEE surveyed from 2003 to 2005. When conducting a re-screening of the same sample in 2006–2008. The prevalence and risk of developing new cases of DM in obese people with and without metabolic syndrome (MetS) were analyzed (according to NCEP ATP III criteria). Persons with obesity, but without MetS are designated as: «Metabolically healthy obesity» (MHO). According to the screening survey for 2003–2005 the group of obese people without MetS was 1237 people, and the group of people with obesity and MetS was 1227.

Results: Over the observation period, new cases of DM in people with MHO were determined 6.6%, (82 people), while in the group of obesity with MetS, the frequency of newly diagnosed DM was 17.1%, (210 people), p MetS, new cases of DM were detected 2.5 times more often than in the group of MHO; men have a greater risk of developing diabetes in comparison with women.