ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2019) 63 EP33 | DOI: 10.1530/endoabs.63.EP33

The effects of metabolic dysfunction (obesity diabetes type II) on the cervical epithelium cytology from Pap test survey

Zurab Tsagareli1, Ekaterine Datunashvili2, Ekaterine Melikadze1, Elene Nikobadze1, Tinatin Kvachadze1 & Liana Gogiashvili1

1Iv. Javakhishvili Tbilisi State University, A. Natishvili Institute of Morphology, Tbilisi, Georgia; 2National Institute of Endocrinology, Tbilisi, Georgia.

Abstract: The effects of diabetes type II and obesity on the cervical epithelium reaction were studied on the Georgian population based of Pap-test survey. Goal is to examine the association between obesity, metabolic disorders (diabetes, thyroid dysfunction) and cervical Pap test results. Study group includes 56 patients. According to the Georgian Low, written informed consent was required. From the study population, we used data zf all 56 women aged 23–52 years. The socio - demographic status, level of education (non-high school graduate/ high school graduate), marital status were included. Body mass index was calculated in kg/m2 and divided as obese (BMI > 30 kg/m2) or not obese (BMI ≤30 kg/m2) persons.

Summarizing results were shown that:

1. obesity is strongly associated with a low grade squamous abnormalities and undetermined significance (ASCUS) (2007 Bethesda system).

2. Hypertension, diabetes, thyroid dysfunctions provoke abnormal Pap. Smears - had history of STDs (Trichomonas vaginalis and genital HSV infection).

3. 22% of the morbid obese women, had a history of primary infertility and significant differences in Pap test results, than women without these associations. In conclusion, our study demonstrates an increased prevalence of abnormal Pap test (LSIL), high-risk of infertility and opportunistic endometrial infection compared with nonobese women.

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