ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2019) 63 P714 | DOI: 10.1530/endoabs.63.P714

Low arginine vasopressin levels in patients with central diabetes insipidus is not associated with anaemia

Benedict Morin1,2, Bettina Winzeler1,2, Julie Refardt1,2, Cornelia Imber1,2, Wiebke Fenske3,4, Clara Sailer1,2, Andreas Holbro5 & Mirjam Christ-Crain1,2

1Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland; 2Department of Clinical Research, University Hospital Basel, Basel, Switzerland; 3University of Leipzig, Department of Endocrinology and Nephrology, Leipzig, Germany; 4Leipzig University Medical Center, IFB AdiposityDiseases, Leipzig, Germany; 5Department of Hematology, University Hospital Basel, Basel, Switzerland.

Background: Arginine vasopressin (AVP) is released upon osmotic stimulation or hypovolemia in order to maintain water balance. A recent study showed a role of AVP in haematopoiesis by stimulating red blood cell precursors, suggesting a higher risk of anaemia in patientis with AVP deficiency. The aim of this study was to explore the effect of low AVP levels in patients with central diabetes insipidus (cDI) and primary polydipsia (PP) on haemoglobin and the prevalence of anaemia.

Methods: We analysed data of 164 patients with either cDI (70, 43%) or PP (94, 57%) and of 30 healthy volunteers collected in the context of two prospective diagnostic studies. In all participants, a standardized work-up was performed including assessment of medical history, drugs, clinical parameters and laboratory values including copeptin, haemoglobin and haematocrit. Anaemia was defined according to WHO criteria as haemoglobin values of <120 g/l in women and <130 g/l in men.

Results: Patients with cDI (61% female, mean age: 46 years) were older than patients with PP (69% female, mean age: 36 years) and healthy volunteers (57% female, mean age: 31 years), P<0.001. Basal meancopeptin values were lower in patients with cDI (2.63 pmol/l (±1.08)) than with PP (13.91 pmol/l (±42.76)) and healthy volunteers (24.76 pmol/l (±57.49)), P=0.02. The prevalence of anaemia was low in all participants, n (%): 5 (7.1), 2 (2.2) and 3 (10) in cDI, PP and in healthy volunteers, P=0.15. Mean haemoglobin values were similar in all groups: 139 g/l (±15.85), 140 g/l (±13.16) and 139 g/l (±13.05) in patients with cDI, PP and healthy volunteers, respectively, P=0.90, as were mean haematocrit values with 0.41% in all three groups (P=0.85).

Conclusion: Chronically low AVP levels in patients with cDI and PP do not to affect haemoglobin levels and prevelance of anaemia in a stable situation.

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