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Endocrine Abstracts (2019) 63 P1207 | DOI: 10.1530/endoabs.63.P1207

ECE2019 Poster Presentations Thyroid 3 (74 abstracts)

Clinical, histological and evolutive characteristics of multifocal thyroid carcinomas

Kenza Sekkat , Siham El Aziz & Asma Chadli


Department of Endocrinology, Diabetology and Metabolic Diseases University Hospital Center Ibn Rochd, Laboratory of Neuroscience and Mental Health Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.


Introduction: Differentiated thyroid carcinoma (DTC) can often be multifocal. However, the multifocal character as associated with a more pejorative prognosis remains controversial. The objective of our study is to describe the clinical, histological and evolutionary characteristics of multifocal DTCs.

Materials and methods: Retrospective study including 159 patients diagnosed with a multifocal CDT, treated at the endocrinology service of the University Hospital of Casablanca between 1986 and 2018. The statistical analysis was performed by the IBM SPSS Statistics 25 software.

Results: The average age of our patients was 47±13 years with a clear female predominance of 153 women against 6 men. All patients underwent total thyroidectomy. Only 6% underwent lymph node dissection. 88% of patients benefited from radioactive iodine treatment. Papillary carcinoma with follicular differentiation was the most common histological type found in 42% of patients, other histological variants were found including classical papillary carcinoma in 45%, oncocyte differentiation in 3 patients and trabecular differentiation in one patient. Two patients had a non-invasive follicular thyroid tumor with papillary nuclei (NIFTP). Tumor foci were found in the 2 thyroid lobes in 62% of cases. Lymph node invasion was found in 9% of cases, 2% of subjects had distant metastases. Complete remission was noted in 65% of patients, a biologically incomplete response in 6%, and morphologically incomplete response in 10% of cases. Bivariate analysis of the factors influencing the occurrence of locoregional or distant metastasis showed a statistically significant difference in the case of male sex (P=0.009) and vascular invasion on the pathological study (P <0.001).

Discussion: In our present study, multifocality was unrelated to an increase in the aggressiveness of differentiated thyroid carcinomas. However, a study with a larger follow-up would be interesting to evaluate the long-term prognosis of these so-called tumors.

Volume 63

21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

European Society of Endocrinology 

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