Endocrine Abstracts (2019) 63 P471 | DOI: 10.1530/endoabs.63.P471

Parathyroid hormone (PTH) levels are not associated with cancer in patients with primary hyperparathyroidism

Georgios Boutzios1, Nefeli Tomara2, Eugenia Kotsifa2, Eleni Koukoulioti1, Zoe Garoufalia2, Elefterios Spartalis3 & Gerasimos Tsourouflis2


1Department of Pathophysiology, Medical School, National and Kapodistrian University of Athens,, Athens, Greece; 2Second Department of Propaedeutic Surgery, Medical School, National and Kapodistrian University of Athens, Athens, Greece; 3Laboratory of Experimental Surgery and Surgical Research ‘N. S. Christeas’, Medical School, National and Kapodistrian University of Athens, Athens, Greece.


Introduction: The development of malignancies in patients with Primary Hyperparathyroidism (PHP) occurs in the context of Multiple Endocrine Neoplasia (MEN) Syndrome. The association of PTH levels with cancer in patients with sporadic PHP has not been clarified. The aim of this study was to investigate whether PTH levels are related to the presence of thyroid cancer (TH) or other types of cancer in patients with PHP.

Methods: We included patients with biochemical diagnosis of PHP based on PTH, Calcium, Albumin, Phosphorus, Creatinine and 25 (OH) Vitamin D3 levels, who had undergone parathyroidectomy. Exclusion criteria were secondary, tertiary hyperparathyroidism and parathyroid hyperplasia in histology.

Results: 84 (69 females) patients with mean age 63.13 years were included in the study. The mean PTH levels were 133.6 pg/ml (47–398). 19 patients developed any type of cancer, and 5 of them developed TC. The mean PTH levels were 132.8 pg/ml in patients who did not develop TC, while in patients with TC the mean PTH levels was 145.8 pg/ml (P=0.675). Furthermore, among patients with any type of cancer, PTH levels were higher (146.18 pg/ml) compared to patients who did not develop cancer, whose PTH levels were 129.92 pg/ml (P=0.35).

Conclusion: PTH levels, although higher in patients with any type of cancer and PHP, show no statistically significant correlation. Larger prospective studies are needed to explore a possible association between these entities.

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