ECE2019 Poster Presentations Calcium and Bone 2 (59 abstracts)
Primary hyperparathyroidism with ectopic mediastinal adenoma complicated with brown tumors
Marwa Ben Jemaa 1 , Chedia Zouaoui 1 , Kawther El Arbi 1 , Asma Zargni 2 & Haroun Ouertani 1
1Military hospital, tunis, Tunisia; 2military hospital, tunis, Tunisia.
Abstract: Brown tumors also known as osteitis fibrosa are a very rare complications of primary hyperparathyroism that occur in less than 2% of patients suffering from any form of hyperparathyroidism. Parathormone increases osteoclastic activity in the bones causing cystic bony changes, it’s a reparative cellular process. Common sites of brown tumor are the ribs, clavicle, long bones and pelvic girdle. Our case is 55 years old tunisian men who was admitted to orthopedic department for bilateral knee pain evolving since 2 years. On laboratory analysis a primary hyperparathroidism was discovered, the analysis showed a malignant hypercalcemia (Ca=3.3 mmol/l), hyperparathyroidism (PTH=848 pg/ml), hypophosphatemia (P=0.75 mmol/l). Cervical echography didn’t show any parathroid adenoma. The cervico-thoracic scan showed a retrosternal adenoma compatible with un ectopic parathyroid adenoma. Bone scintigraphy showed multiple bone lesions of sternum, costs, left humerus and right femur evoking brown tumors. Our patient had an adenomectomy and the histopathological examination showed a 3 cm benign parathyroid hyperplasia. Our patient had a post surgical symptomatic hypocalcemia (ca=1.87 mmol/l), he received a calcium intraveinous supplementation then a standard vitamin D analogues and calcium treatment.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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