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Endocrine Abstracts (2019) 63 S5.2 | DOI: 10.1530/endoabs.63.S5.2

The Netherlands.


Alterations in (small) intestinal microbiota are associated with aberrant insulin secretion. We previously showed that fecal transplantation (infusing intestinal microbiota from lean donors) in insulin resistant subjects has beneficial effects on the recipients’ microbiota composition and glucose metabolism via altering fecal SCFA producers levels (Vrieze, Gastroenterology 2012). Followup studies suggest that this beneficial effect can be divided in responders and non responders based on SCFA producing microbiota engraftment and beneficial metabolites (Kootte, Cell Metabolism 2017). In line, unpublished data from our group suggest that FMT in new onset type 1 diabetes patients also can drive beneficial effects on residual betacell function (de Groot/Roep/Nieuwdorp, manuscript in preparation). To our surprise however, oral butyrate supplementation had no beneficial effect on glucose metabolism in both type 1 and type 2 diabetes subjects (de Groot/Roep/Nieuwdorp, submitted; Bouter/Nieuwdorp, Clin Transl Gastro 2018). Combined our data thus suggest that specific missing intestinal (SCFA producing) strains might be developed as therapeutics for treatment in both type 1 and type 2 diabetes.

Volume 63

21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

European Society of Endocrinology 

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