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Belgian Endocrine Society 2019

BES 2019

Sexual Dimorphism in Bone Size is Mediated by Neuronal ER alpha (ERα) Signaling in Females during Late Puberty

ea0064002 | Sexual Dimorphism in Bone Size is Mediated by Neuronal ER alpha (ERα) Signaling in Females during Late Puberty | BES2019

Sexual Dimorphism in bone size is mediated by neuronal ER alpha (ERα) signaling in females during late puberty

Nari Kim , Ferran Jardi , Rougin Khalil , Leen Antonio , Dieter Schollaert , Ludo Deboel , van Lenthe GH , Brigitte Decallonne , Geert Carmeliet , Claes Ohlsson , Lagerquist Marie K , Frank Claessens , Dirk Vanderschueren

Introduction: Pubertal sex steroids are indispensable for peak bone mass acquisition as well as skeletal sexual dimorphism. In males, both androgen receptor (AR) and estrogen receptor alpha (ERα) are required for optimal periosteal cortical bone expansion, while estrogens limit bone size in females. In early puberty, estrogens directly stimulate longitudinal growth via ERα in cartilage, but also indirectly via growth hormone (GH) and insulin-like growth factor I (IGF...