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Belgian Endocrine Society 2019

BES 2019

Impact of changes in muscle secretome in the improvement of glucose homeostasis induced by bariatric surgery

ea0064003 | Impact of changes in muscle secretome in the improvement of glucose homeostasis induced by bariatric surgery | BES2019

Impact of changes in muscle secretome in the improvement of glucose homeostasis induced by bariatric surgery

Orioli L , Szczerbak M , Navez B , Lause P , de Barsy M , Loumaye A , Deswysen Y , Thissen JP

Introduction: Type 2 diabetes results from insulin resistance and B-cell failure. Bariatric surgery is an effective therapeutic modality for type 2 diabetes. Indeed, it induces high remission rates through improved insulin sensitivity and secretion. While the critical role of skeletal muscle in glucose homeostasis has long been known, its role as an endocrine organ secreting peptides, called myokines, has recently been identified. Some of these myokines were shown to influence...