Searchable abstracts of presentations at key conferences in endocrinology
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European Congress of Endocrinology 2021

Online
22 May 2021 - 26 May 2021

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The European Congress of Endocrinology provides a global platform for the international endocrine community to discuss the latest advances in the field.

Symposia

Symposium 13: TGF-β signalling in ovaries in women with PCOS

ea0073s13.1 | Symposium 13: TGF-β signalling in ovaries in women with PCOS | ECE2021

Interplay between androgens and TGF-β signalling in the ovary

Knight Phil G

Theca cells are indispensable for female reproduction being the source of androgens required for follicular oestrogen synthesis and also for interacting with androgen receptors in the ovary and other somatic tissues. Differentiated theca interna cells acquire responsiveness to LH and other endocrine signals, including insulin, that upregulate the steroidogenic pathway leading to androgen biosynthesis. In addition, numerous intraovarian factors of thecal, granulosal and/or oocy...

ea0073s13.2 | Symposium 13: TGF-β signalling in ovaries in women with PCOS | ECE2021

LH-receptor activity and interaction with TGF-β family members in women with PCOS

Owens Lisa , Kristensen Stine Gry , Lerner Avi , Hanyaloglu Aylin , Hardy Kate , Andersen Claus Yding , Franks Stephen

The luteinising hormone/chorionic gonadotropin receptor (LHCGR) plays an essential role in ovarian follicular function, mediating the action of LH on theca cell steroidogenesis and, in the preovulatory follicle, on granulosa cell (GC) steroid production and the ovulatory cascade. Following ovulation, LH (and CG) are responsible for maintenance and function of the corpus luteum. Arrested antral follicle development in PCOS is characterised by premature responsiveness of GCs to ...

ea0073s13.3 | Symposium 13: TGF-β signalling in ovaries in women with PCOS | ECE2021

Cell-specific expression of TGF-β family members in follicles of women with and without PCOS

Bøtkjær Jane Alrø

Polycystic ovary syndrome (PCOS) is a common endocrine disorder, affecting 5 – 10% of women of reproductive age, and is the major cause of anovulatory infertility. The mechanisms of reproductive dysfunction in PCOS remain to be clarified. Members of the TGF-β and IGF signalling pathway have been suggested to be involved in aberrant follicle development in women with PCOS. This talk will focus on previous and ongoing research that we carried out in Denmark and the Un...