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Endocrine Abstracts (2022) 81 OC10.2 | DOI: 10.1530/endoabs.81.OC10.2

ECE2022 Oral Communications Oral Communications 10: Diabetes, Obesity, Metabolism and Nutrition 3 (6 abstracts)

Success in implementing changes in macronutrients intake in a high-protein and high-unsaturated fatty acids dietary intervention: 36-months results of the NutriAct randomized controlled multi-center trial

Laura Pletsch-Borba 1 , Charlotte Wernicke 1 , Nina Meyer 1 , Thu Nguyen 1 , Anne Pohrt 2 , Christiana Gerbracht 3 , Andreas Pfeiffer 1 , Joachim Spranger 1 & Knut Mai 1


1Charité Universitätsmedizin Berlin, Endocrinology and Metabolism, Berlin, Germany; 2Charité Universitätsmedizin Berlin, Institute of Biometry and Clinical Epidemiology, Germany; 3Human Study Center, German Institute of Human Nutrition Potsdam-Rehbrücke, Germany

Background & Aims: NutriAct is a 36-month randomized controlled multi-center trial aiming to analyze the effects of a dietary pattern focusing on a high-protein and high-unsaturated fatty acids (UFA) intake on healthy aging. We aimed to explore changes in intake of macronutrients and determine factors associated with a successful modulation of dietary pattern after 36 months in elderly community dwelling participants.

Methods: 502 participants were randomized into a usual care control group including dietary recommendations of the German Nutrition Society or an intervention group, which used supplementation of rapeseed oil and specifically designed foods as well as repetitive advices to implement a food pattern based on high intake of predominantly plant proteins and UFA. Food intake was repeatedly assessed by 3-day food records at months 0, 3, 6, 12, 24 and 36 months. Linear regression models were carried out to investigate differences in changes in macronutrients intake between the intervention arms and determinants of modulation of dietary pattern during the intervention in 36 months.

Results: 148 intervention and 164 control participants (median age 66 y, 36% males) with available food records at baseline and at month 36 and were included. The intervention resulted in higher intake of protein, mono- and polyunsaturated fatty acids (MUFA and PUFA) and fiber, and lower carbohydrate and saturated fat consumption (all P<0.05). While individuals who were already at baseline closer to the NutriAct pattern also achieved a diet closer to the proposed pattern at month 36, the strongest relative changes of dietary behavior were seen in those with dietary patterns further away from the proposed pattern at baseline. Sex, age, baseline BMI, education, comorbidities, smoking, cognitive status and shared household were not associated to a higher implementation of the proposed diet.

Changes in macronutrients intake between baseline and month 36 between intervention and control groups
MacronutrientBeta coefficient (95% CI)P-value
Protein (%E)2.35 (1.44, 3.25)<0.01
Total fat (%E)2.70 (1.00, 4.39)<0.01
Carbohydrate (%E)-4.83 (-6.60, -3.05)<0.01
Sat. Fatty acids (%E)-2.30 (-3.24, -1.32)<0.01
PUFA (%E)3.57 (2.70, 4.44)<0.01
MUFA (%E)0.82 (0.08, 1.60)0.03
Fiber (%E)3.64 (1.72, 5.56)<0.01

Conclusions: A successfully modification of dietary pattern was achieved by the intervention within 36 months. Baseline dietary habits were substantial determinants predicting change in dietary pattern.

Volume 81

European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

European Society of Endocrinology 

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