ECE2022 Poster Presentations Calcium and Bone (68 abstracts)
The impact of age on quality of life and frailty outcomes after parathyroidectomy in patients with primary hyperparathyroidism
Theodosios S. Papavramidis 1 , Panagiotis Anagnostis 2 , Ioannis Pliakos 1 , Georgios Tzikos 1 , Angeliki Chorti 1 , Kalliopi Kotsa 3 & Antonios Michalopoulos 1
11st Propedeutic Department of Surgery, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece; 2Aristotle University of Thessaloniki, Unit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynecology, Medical School, Thessaloniki, Greece; 3Division of Endocrinology and Metabolism and Diabetes Center, First Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
Objective: Parathyroidectomy (PTx) improves quality of life (QoL) in patients with primary hyperparathyroidism (PHPT). Whether this effect is modified according to the patients’ age is unknown. The aim of this study was to evaluate the impact of age on the effect of PTx on QoL and frailty in patients with PHPT, six months post-PTx.
Methods: This was a prospective cohort study, including patients with PHPT, admitted from January 2016 to December 2019, divided into two categories: younger (≤65 years old) and older ( >65 years old). QoL was assessed with the Pasieka questionnaire (PAS-Q) two days pre- and six months post-operatively. Frailty was also assessed at the same time intervals, with the Frailty Index (FI).
Results: One-hundred thirty-four patients (younger group: 96 patients, mean age 50.4±9.8 years; older group: 38 patients, mean age 72.1±4.9 years) were included. PTx resulted in a significant reduction in PAS-Q score in both groups. Notably, a greater reduction in ‘mood swings’, ‘irritability’, ‘itchy skin’ and ‘feeling thirsty’ PAS-Q domains was observed in younger group. In contrast, a greater decrease in ‘bone-pain’, ‘tiredness’, ‘weakness’, ‘joint pain’, ‘getting off chair’ and ‘headaches’ items was observed in older group. Moreover, PTx led to a decrease in FI only in this group.
Conclusions: PTx leads to an improvement in QoL both in older ( >65 years) and younger (≤65 years) patients with PHPT, attributed to a differential effect on PAS-Q items. Frailty improves only in the older group.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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