SFEBES2022 Poster Presentations Metabolism, Obesity and Diabetes (96 abstracts)
Metabolic syndrome and obesity in IBD patients: how common?
Iulia Soare 1 , Anca Sirbu 1,2 , Mircea Diculescu 1,3 , Bogdan Radu Mateescu 1,4 , Cristian George Tieranu 1,5 , Sorina Martin 1,6 & Simona Fica 1,7
1Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; 2Endocrinology Department-Elias Hospital, Bucharest, Romania; 3Gastroenterology Department Fundeni Clinical Institute, Bucharest, Romania; 4Gastroenterology- Colentina Hospital, Bucharest, Romania; 5Gastroenterology Department- Elias Hospital, Bucharest, Romania; 6Endocrinology Department Elias Hospital, Bucharest, Romania; 7Endocrinology Department- Elias Hospital, Bucharest, Romania
Introduction: Although patients with inflammatory bowel disease (IBD) -Crohn’s disease (CD) and ulcerative colitis (UC)- are considered prone to malnutrition, studies have shown an increased risk for obesity, especially visceral obesity and metabolic syndrome (MetS). Possible mechanisms involved include dysbiosis, gut microbiome and chronic inflammation. The aim of the study was to assess the prevalence of MetS and obesity in a group of IBD patients.
Methods: Anthropometric data were collected, and all patients underwent blood tests and body composition data using dual-energy X-ray assessment (DXA) whole body. MetS was diagnosed using IDF criteria.
Results: 81 adult patients (48 with CD and 33 with UC), median age 42 (IQR 23), were included in the study. 65% were younger than 50 years. Their median BMI was 24.5 (7.5) kg/m2, range 12.4-41.3 kg/m2. Of them, 40.7% had a BMI >25 kg/m2, 23% were overweight, and 17% had obesity. Only 2% of them were underweight. MetS was present in 20.9% of the patients, with a higher prevalence in UC than CD patients (30.3% vs14.5%). However, approximately 47% were younger than 50 years. Comparative analysis between UC and CD did not show significant differences in weight, BMI, waist or hip circumference. As for the metabolic parameters, triglycerides were statistically higher in CD patients (103 (65) vs 79 (57) mg/dl, P<0.001). Moreover, although not included in MetS, VAT was higher in CD than UC patients (807 (1337) vs 549 (1337) mm3, P=0.05).
Conclusions: MetS is common in IBD patients, even in younger ones. Although higher prevalence in UC, CD patients seemed to have a higher risk for visceral obesity, which could lead to increased cardiovascular risk. Follow-up studies should be considered.
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Endocrine Abstracts
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