Endocrine Abstracts

Introduction: Brown tumors result from the destruction of bone occurring especially in regions where bone resorption is rapid with hemorrhage and repa-rative granulation tissue replacing the normal tissue. This bone lesion can affect any part of the skeleton. It results from uncontrolled hyperparathyroidism in patients with chronic renal failure.

Objective: The aim of this report is to describe the management and the evolution after treatment of brown tumors in patients with chronic renal failure.

Method: This is a retrospective study including 5 patients with chronic renal failure who developed brown tumors due to secondary or tertiary hyperparathyroidism. This study was carried out from 2008 to 2022.

Results: The average age was 38 years predominantly males (sex ratio (M/F)=1.5). The tumor was located in: the mandible (1 case), the maxilla and the mandible (1 case), the sternum (1 case) and the femora (2 cases). The mean serum calcium level was 1.90 mmol/l. The mean phosphoremia level was 2.20 mmol/l. The mean PTH level was 1500 pg/l. All patients had subtotal parathyroidectomy. Histologic examination of the gland showed parathyroid hyperplasia in all cases. No patient underwent intervention on the tumor. The evolution after surgery was favorable in all cases, with clinical and radiological stabilization of bone lesions in 2 cases and spontaneous regression without recurrence in 3 patients.

Conclusion: Patients with chronic renal failure may develop brown tumors in advanced stages of the disease as a result of uncontrolled hyperparathyroidism. Treatment is based on reducing the levels of PTH, either through medical management, or surgery.