Significance of Determining Inflammatory Markers and Carotid Artery Intima Media Thickness values in the Detection of Coronary Heart Disease in Asymptomatic Patients with Type 2 Diabetes

Gabrijela Malesevic; Snjezana Popovic Pejicic; Tamara Kovacevic; Ljiljana Kos; Bojan Stanetic; Valentina Soldat Stankovic; Ivona Risovic

doi:10.1530/endoabs.90.EP240

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Endocrine Abstracts (2023) 90 EP240 | DOI: 10.1530/endoabs.90.EP240

ECE2023 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (355 abstracts)

Significance of Determining Inflammatory Markers and Carotid Artery Intima Media Thickness values in the Detection of Coronary Heart Disease in Asymptomatic Patients with Type 2 Diabetes

Gabrijela Malesevic ¹ , Snjezana Popovic Pejicic ² , Tamara Kovacevic ³ , Ljiljana Kos ³ , Bojan Stanetic ³ , Valentina Soldat Stankovic ¹ & Ivona Risovic ¹

Err

Author affiliations

¹University Clinical Centre of the Republic of Srpska, Medical Faculty, University of Banja Luka, Department of Endocrinology, Banja Luka, Bosnia and Herzegovina; ²Medical Faculty, University of Banja Luka, Banja Luka, Bosnia and Herzegovina; ³University Clinical Centre of the Republic of Srpska, Medical Faculty, University of Banja Luka, Department of Cardiology, Banja Luka, Bosnia and Herzegovina

Introduction: Increased levels of high-sensitivity C-reactive protein (hs-CRP) and interleukin 6 (IL-6) accelerates atherosclerosis and occurrence of cardiovascular complications in patients with type 2 diabetes (T2D). Intima-media thickness (IMT) is a surrogate marker of atherosclerosis in patients with T2D.

Aim: The aim of the study was to evaluate the significance of determining inflammatory markers IL-6, hs-CRP and IMT, as atherosclerosis markers, during a screening for presence of Coronary Heart Disease (CHD) in asymptomatic patients with T2D.

Methods: The study included 169 patients with T2D, without any symptoms and signs of CHD. Ergometric testing proved or ruled out the presence of CHD. Carotid ultrasonography was performed and IMT was measured. The levels of hs-CRP and IL-6 were determined by ELISA.

Results: Age, HbA1c, LDL cholesterol and albuminuria values were significant predictors of silent CHD (P<0.05). Other analysed risk factors: gender, smoking, duration of T2D, BMI, hypertension, total cholesterol and triglycerides did not show statistical significance in the prediction of CHD. It was proven that there was a greater possibility of the presence of silent CHD in asymptomatic patients with T2D with higher values of IMT(P<0.05), IL-6 (P<0.05) and hs-CRP (P<0.001).

Keywords: diabetes mellitus, coronary heart disease, inflammatory markers, intima-media complex