ECE2023 Poster Presentations Adrenal and Cardiovascular Endocrinology (72 abstracts)
The Relationship Between Autonomic Cortisol Secretion and Metabolic Diseases in Cases with Adrenal Incidentaloma
Beril Turan Erdogan 1 , Berna Evranos Ogmen 2 , Muhammed Sacikara 1 , Cevdet Aydin 2 , Oya Topaloglu 2 , Reyhan Ersoy 2 & Bekir Cakir 2
1Ankara City Hospital, Department of Endocrinology and Metabolism, Ankara, Turkey; 2Yildirim Beyazit University Faculty of Medicine, Department of Endocrinology and Metabolism, Ankara, Turkey
Backgorund: Adrenal incidentalomas (AI) are lesions discovered incidentally on imaging without clinical symptoms or examination findings. AI can produce hormones in 5-30% of cases. Autonomic cortisol secretion (ACS) is the most common of these. Although ACS is asymptomatic, it increases the risk of metabolic disorders.
Methods: Patients aged ≥18 years with adrenal adenoma and upper abdominal MRI who presented and were examined in the endocrinology outpatient clinic, had their data retrospectively documented. Comorbidities, examinations and hormonal tests and results of these patients were evaluated. Those who failed dexamethasone suppression tests (cortisol >1.8 g/dl) and did not have Cushing’s syndrome were classified as ACS.
Results: Among the 465 patients, 311 (66.9%) were women with a mean age of 54.8±10.2 (18-82). Of the patients, 31.4% had diabetes mellitus (DM), 53.8% had hypertension (HT), 30.8% had hyperlipidemia (HL), 11.8% had coronary artery disease (CAD), 1.3% had heart failure (HF) and. Hormone testing revealed that 31 (6.6%) of the patients had primary aldosteronism, 7 (1.5%) had pheochromocytoma, and 75 (16.1%) had ACS. Patients with and without ACS were compared for the presence of other additional diseases and adenoma size (Table-1). DM, HT and HL were higher in the ACS group (P<0.05, for each). Adenoma size was larger in the ACS group (P<0.05). Although the gender distribution was similar in both groups (P>0.05), the OCS patient was older (P=0.006).
| Autonomic cortisol secretion | Yes n=75 | No n=390 | P |
| Sex, Woman/Man | 56/19 | 255/135 | 0.11 |
| Age (years), mean | 57.8±10.8 | 54.2±9.9 | 0.006 |
| Size of adenoma (mm), median (min-max) | 25 (10-54) | 18 (10-60) | <0.001 |
| T2DM % | 41.3 | 29.5 | 0.04 |
| HT % | 69.3 | 50.8 | 0.003 |
| HL % | 41.3 | 28.7 | 0.03 |
| CAD % | 18.7 | 10.5 | 0.04 |
| HF % | 2.7 | 1 | 0.25 |
| Osteoporosis % | 31.8 | 35 | 0.95 |
| T2DM type 2 diabetes mellitus, HT hypertension, HL hyperlipidemia, CAD coronary artery disease, HF heart failure | |||
Conclusion: Individuals with large adenomas are more likely to have ACS. Large adrenal adenomas should be monitored for ACS and associated cardiometabolic risks, as well as necessary treatments.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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