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Endocrine Abstracts (2024) 99 P211 | DOI: 10.1530/endoabs.99.P211

1Clinic of Endocrinology, Diabetes and Metabolic Diseases, University Clinical Centre of Centre, National Centre for Infertility and Endocrinology of Gender, Belgrade, Serbia; 2Faculty of Medicine, University of Belgrade, Belgrade, Serbia; 3Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia; 4General Hospital of Novi Pazar, Department of Psychiatry, Novi Pazar, Serbia

Introduction: The interplay between obesity and hormones has a profound impact on women’s reproductive health, reducing the likelihood of successful conception.

Methods: We performed a 6-month longitudinal study. The inclusion criteria were: women aged 20-40 with infertility, regular anovulatory menstrual cycles, BMI 35-40 kg/m², unrelated to other diseases. 30 eligible women were categorized into three groups: Group 1 (G1) received motivational interviews, hospitalizations, and nutritionist check-ups; Group 2 (G2) underwent hospitalization and nutritionist check-ups, while Group 3 (G3) served as the control without any interventions.

Results: G1-mean age 32.2±5.5, mean starting BMI (BMI1) 35.6±6.4 kg/m², G2-mean age 36.4±4.1, mean BMI1 38.2±4.9 kg/m², G3-mean age 33.7±4.9, mean BMI1 35±1.0 kg/m², with no difference in age or BMI between the groups (P>0.05). After 6 months, G1 lost 15.5±7.4% of their initial body weight (BW) i.e 14.5±9.09% of the BMI1, G2 lost 10.9±8.07% BW i.e. 11.05±8.2% BMI1, G3 lost 0.38±1.8% BW i.e. 0.41±1.08% BMI1 (P<0.0001). When compared based on percentage of BMI loss, there was a difference between G1-G3 (P<0.001), G1-G2 (P<0.01), but no difference between G2-G3 (P>0.05). When compared based on percentage of BW loss, there was a difference between G1-G3 (P<0.0001), G2-G3 (P=0.02), but no difference between G1-G2 was observed (P>0.05). After 6 months, only in G1 progesterone reached ovulatory levels 10.88± 8.72 nmol/l (P<0.05), where in G2/8.6±5.9 nmol/l and G3/3.4±1.65 nmol/l, this effect was absent (P<0.05). Progesterone levels were significantly higher in G1 than in G3 (P=0.034) although there was no difference between the groups G1 and G2 (P>0.05) and G2 and G3 (P>0.05). The number of hospitalizations with motivational interview was a linear predictor of percentage of weight loss (P<0.0001, B=3.785, 95% CI 2.08-5.48, OR 4.553).

Conclussion: The motivational interview emerges as a promising and effective method with a significant role in the reduction of excessive body weight. The combined approach of motivational interviews and hospitalization presents a synergistic strategy in the comprehensive treatment of obesity and its associated reproductive health challenges.

Volume 99

26th European Congress of Endocrinology

Stockholm, Sweden
11 May 2024 - 14 May 2024

European Society of Endocrinology 

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