Endocrine Abstracts

Introduction: Primary hyperparathyroidism is a frequent pathology due to inappropriate PTH secretion. Its seriousness lies in the occurrence of multiple cardiovascular, bone and renal complications responsible for recurrent urinary lithiasis.

Patients and methods: In order to better assess the prevalence and to understand the factors favouring the occurrence of renal calculi, 60 patients were evaluated in a prospective study conducted at the Rabat military hospital in the endocrinology department over a 7-month period from January 2024 to July 2024. Patients with a primary hyperparathyroidism profile were included in the study. Patients with secondary hyperparathyroidism, tertiary hyperparathyroidism or marx syndrome, as well as patients with stones from another cause: hyperuricemia, medical

Results: The prevalence of subjects with kidney stones was around 30%. The mean age was 51.9±14.3 years, and the gender ratio (women/men) was 5.4. Compared with those without renal calcifications, the group with renal calcifications had: - low creatinine levels (67 ± 25.1 vs. 74.6 ± 17.5 µmol/l, P= 0.03). -In addition, their fractional calcium excretion (calcium/creatinine excretion ratio) was elevated (0.91 ± 0.28 vs. 0.74 ± 0.40 µmol/, P= 0.02). -Calcemia was higher (P=0.03). -Natriuresis: higher above 8 mmol/ kg/24h (P= 0.02) The other variables measured were similar in both groups. No biochemical was predictive of renal calcifications in multiple regression analysis.

Conclusion: This study confirms that the occurrence of calcifications in primary hyperparathyroidism is associated associated with lower creatinemia and higher fractional calcium excretion, as well as elevated as well as elevated calcemia.