Endocrine Abstracts

Primary hyperaldosteronism, is a well-documented cause of secondary hypertension characterized with resistant hypertension, hypokalaemia and metabolic alkalosis, However, its initial presentation as Hypokalaemia induced rhabdomyolysis with hormal blood pressure is rare. We report a case of Hypokalaemia induced rhabdomyolysis encountered as an initial presentation of Conns syndrome in a 38-year-old lady presented with severe myalgia, cramps, quadriparesis and fatigability. Her Serum potassium was found to be 1.68 mmol/L (reference ranges of 3.3–5.5). Her neurological assessment showed power of 3/5 in all limb with generalised hyporeflexia with intact sensory and cerebellar modality, MRI brain study was reported Normal. She was commenced on IV Fluids and potassium replacement following which CK and myoglobin levels gradually improved, but the serum potassium recovery was poor. Further evaluations strongly suggested Primary aldosteronism by an aldosterone-producing adenoma as the cause of her findings.

Discussion: Hypokalemia-induced rhabdomyolysis is a rare and potentially life-threatening condition that can arise from a variety of underlying disorders. Through this report, we aim to highlight the need for clinicians to remain vigilant in identifying rare but serious conditions like Conns syndrome, which, although rare, should not be dismissed when faced with appropriate clinical presentations. This case serves as an important teaching point that early detection and intervention are crucial for favorable outcomes.