SFEBES2025 Poster Presentations Late Breaking (68 abstracts)
Inceptor is essential to maintain thyroid function in mice
Pei Xu 1,2 , Leopold Schomann 1,2 , Christos Karampelias 1 & Heiko Lickert 1,2
1Helmholtz Munich, Munich, Germany. 2Technical University of Munich, Munich, Germany
Insulin inhibitory receptor (inceptor) is highly expressed in various secretory cells and plays an important role in granule formation. The thyroid consists of secretory cells including thyrocytes and c cells which produce thyroxin and triiodothyronine to regulate and maintain metabolic homeostasis. However inceptor expression and function has never been investigated in thyroid. Inceptor-KO mice shows higher FT3 levels comparing to WT mice but doesn’t show any proliferation difference. And isolation thyrocytes for 3D culture, inceptor-KO has more thyroid follicles formation at day 6 and thyroid-related markers (PAX8 and Nis) expression is higher, indicating inceptor-KO thyroid organoid more mature than WT. Inceptor-KO promotes hyper functional thyroid, and inceptor expression in thyroid is important to maintain thyroid function balance.
Volume 109
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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