Endocrine Abstracts

This study aims to provide associations of BPA, AGEs, Kisspeptin, and Melatonin with PCOS. The study included 133 PCOS and 65 control females. We measured serum BPA, AGEs, kisspeptin, and melatonin. Statistical differences were derived using Mann-Whitney U, ROC curve, and Spearman’s correlation tests. Serum BPA levels were quantified in 109 PCOS and 45 controls. PCOS had significantly higher serum BPA (32.82 vs 21.27 ng/ml, P < 0.05). Phenotype D had BPA levels lower than controls. The AUC was 0.7, with sensitivity and specificity ranges 61-62%. The levels of AGEs were quantified in 83 PCOS and 40 controls. The mean levels of AGEs were significantly higher in PCOS (12.08 vs 4.79 ng/ml; P = 0.0001). A positive correlation was observed between AGEs and BMI (r= 0.225, P < 0.05). The AUC was 0.63, with sensitivity and specificity of 58-60%. Serum kisspeptin levels were quantified in 133 PCOS and 65 controls. Serum kisspeptin concentrations were higher in the PCOS (98.34 vs 57.02 pg/ml; P = 0.00074). Phenotype D showed the most significant difference in the kisspeptin levels (130.22 pg/ml; P = 0.00066). A negative correlation was observed between kisspeptin and testosterone (r=-0.230, P < 0.05). The AUC in PCOS was 0.6, with sensitivity and specificity between 62-65%. Phenotype D showed an AUC of 0.728. Serum melatonin levels were quantified in 110 PCOS and 54 controls. Melatonin concentrations were higher in the PCOS (106.08±50.47 vs 50.32±46.34 pg/ml; P < 0.05). The hyperandrogenic PCOS showed the most significant differences in melatonin (P < 0.00001). A positive correlation was observed between melatonin and LH in the phenotype D (r = .961, P = 0.0001). The AUC value for hyperandrogenic PCOS was >0.8. None of the markers are strongly associated with PCOS as a whole. However, melatonin seems a good (AUC >0.8) marker for hyperandrogenic PCOS and kisspeptin for non-hyperandrogenic PCOS, underscoring the significance of our work.