Incidentaloma: pathological and biochemical analysis management in the disorders of the adrenal medulla in albania popullation

Brunilda Mezani

doi:10.1530/endoabs.110.EP58

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Endocrine Abstracts (2025) 110 EP58 | DOI: 10.1530/endoabs.110.EP58

ECEESPE2025 ePoster Presentations Adrenal and Cardiovascular Endocrinology (170 abstracts)

Incidentaloma: pathological and biochemical analysis management in the disorders of the adrenal medulla in albania popullation

Brunilda Mezani ¹

Author affiliations

¹1Department of Biology, University Tirana Albania, 2Department of Medical Laboratory Sciences and Imaging, Western Balkans University Tirana, Albania 3Pathologist in the American Hospital of Tirana. 4Head of pathology department of American Hospital. 5Vice president of the Albanian Society of Pathology. 6Intermedica Clinic, Tirana Albania, Albania, Albania

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Background & Aim: The adrenal incidentaloma is an adrenal tumor discovered by an imaging test that is being done for a control by that is not related to adrenal disease. Pheochromocytoma is a rare tumor that develops in the adrenal medulla, the inner part of the adrenal glands. This tumor leads to the excessive release of catecholamines, resulting in symptoms such as rapid heart rate, high blood pressure, anxiety, intense headaches, excessive sweating, and unintentional weight loss.

Methodology: This study studied Incidentaloma patient with the pheochromocytoma. Levels of catecholamines and their byproducts in the blood and urine are measured. The analysis includes measuring plasma-free metanephrines or fractionated metanephrines in urine. Additional tests, such as measuring total urinary metanephrines, plasma or urinary catecholamines, or urinary vanillylmandelic acid (VMA), will be used to confirm the presence of the tumor.

Results: The study was conducted on patients aged 15-98 years old. In this study, the pathological pathologies and imaging images of the patients are going to be analyzed. We detect elevated levels of catecholamines or their byproducts in the blood and urine of patients with pheochromocytoma. The most accurate tests include measuring plasma-free metanephrines or fractionated metanephrines in urine. Additional tests, such as measuring total urinary metanephrines, plasma or urinary catecholamines, or urinary vanillylmandelic acid (VMA), will be used in future steps to confirm the presence of the tumor.

Conclusion & Future Research: This study highlights the diagnostic value of plasma-free metanephrines and fractionated urinary metanephrines as the most accurate tests for detecting the tumor. Elevated levels of catecholamines and their byproducts provide critical evidence for diagnosis, while additional confirmatory tests, including urinary vanillylmandelic acid and total catecholamine measurements, can strengthen diagnostic accuracy. Early and precise diagnosis is essential to prevent life-threatening complications such as hypertensive crises, arrhythmias, or stroke. Future research should focus on refining diagnostic algorithms, and incorporating novel biomarkers.

Keywords: Adrenal Tumors, Catecholamines, Metadrenalines, Phaeochromocytoma, Hypertension