Endocrine Abstracts

JOINT2404

Background: Cardiovascular disease (CVD) is a common macrovascular complication of type 1 diabetes (T1D) which still remains the leading cause of death even in well-controlled T1D. Over the last decades young patients with T1D have not shared in the overall reduction of cardiovascular morbidity and mortality but instead according to data from recent epidemiological studies showed a striking increase. Therefore, to improve the prognosis of young patients with T1D targeted primary prevention of CVD is crucial e.g., total cardiovascular risk assessment.

Objectives: Assessment and stratification of total CV risk in young patients with T1D living in Minsk.

Methods: The study was based on a retrospective review of young patients with T1D without previous CVD attending the outpatient clinic “Minsk City Clinical Endocrinological Center”. The stratification of CV risk was performed using the Steno T1 Risk Engine (ST1RE). Control group included patients without T1D, for CV risk stratification Framingham risk score was used.

Results: Eighty-eight patients were enrolled (43F, 45M), median age 36 years [IQR 28-41] with onset of T1D 16 [11-25]. Of these, 20,5% (18 patients) had an early onset of T1D 6,5 [5-8,5]. Glycemic control of our young patients with T1D was suboptimal HbA1c – 7,65% [6,7-8,65]. Using the ST1RE algorithm: 23,9% (21 patients) were at high CV risk, 76,1% (67 patients) had moderate and none had low risk. In the control group (n = 88): 95% of patients had low CV risk, 5% had moderate CV risk. The frequency of occurrence of moderate risk was statistically higher in patients with T1D when compared to the control group (76,1% vs 5%, р<0.01).

Conclusions: Our study suggests that further preventive interventions based on accurate CVD risk prediction algorithm is required for primary prevention of CVD in young patients with T1D.

Key words: type 1 diabetes, cardiovascular risk, young patients, prevention, Steno-calculator