Endocrine Abstracts

JOINT488

Background: traditionally associated with bone metabolism, hypovitaminosis D has emerged as a potential cardiovascular risk factor. Although it is a global issue, few studies in Colombia have evaluated its local impact. This study addresses that gap by examining its role as a potentially modifiable cardiovascular risk factor.

Objective: to determine the association between hypovitaminosis D and the development of major adverse cardiovascular events (MACE), as well as the relationship between the severity of hypovitaminosis D and mortality associated with these events in a Colombian population.

Methods: we conducted a retrospective cohort study with 254 patients aged ≥50 years treated between January 2021 and April 2022. Patients were categorized as having insufficient (<30 ng/mL) or sufficient (≥30 ng/mL) vitamin D levels. Demographic, clinical, and paraclinical variables were analyzed alongside MACE occurrence using descriptive statistics and logistic regression models.

Results: fifty percent of patients had vitamin D insufficiency, and 10.2% had severe deficiency (<15 ng/mL), predominantly in women >65 years. Patients with hypovitaminosis D showed a higher incidence of MACE and a 57.1% mortality rate compared to 0% in the sufficient group. In multivariate analysis, chronic kidney disease was the main risk factor for MACE (OR: 6.84; 95% CI: 1.14–40.9), and vitamin D levels <15 ng/mL were associated with increased cardiovascular risk (OR: 4.1; 95% CI: 0.99–17.02).

Conclusion: hypovitaminosis D increases the risk of MACE and mortality, particularly in patients with chronic kidney disease.