Do patients with ehlers-danlos syndrome and a history of fractures have lower bone mineral density?

Jan Domański; Ivan Rychlik; Jakub Podstawka; - Łapan Aleksandra Żuk; Bernadetta Kałuża; Edward Franek

doi:10.1530/endoabs.110.EP183

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Endocrine Abstracts (2025) 110 EP183 | DOI: 10.1530/endoabs.110.EP183

ECEESPE2025 ePoster Presentations Bone and Mineral Metabolism (142 abstracts)

Do patients with ehlers–danlos syndrome and a history of fractures have lower bone mineral density?

Jan Domański ^1,2 , Ivan Rychlik ³ , Jakub Podstawka ^1,2 , Aleksandra Żuk - Łapan ^1,2 , Bernadetta Kałuża ^1,2 & Edward Franek ^2,4

Author affiliations

¹Students Scientific Group of the Medical University of Warsaw at the Department of Internal Medicine, Endocrinology, and Diabetology, National Medical Institute of the Ministry of the Interior and Administration, Warsaw, Poland; ²Department of Internal Medicine, Endocrinology, and Diabetology, National Medical Institute of the Ministry of the Interior and Administration, Warsaw, Poland; ³Department of Internal Medicine, Third Faculty of Medicine, Charles University, and Královské Vinohrady University Hospital, Prague, Czech Republic; ⁴Department of Human Epigenetics, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland

JOINT2230

Background: Joint hypermobility and instability are among the main risk factors for fractures in patients with Ehlers–Danlos syndrome (EDS). Such fractures, which may affect bone biomechanics, may be due to low bone mineral density (BMD). The purpose of this study was to assess bone density in patients with a hypermobile and classical subtype of EDS and a history of fractures.

Material and methods: The study involved a prospective assessment of 30 female patients, with either hypermobile or classical EDS. The patients were divided into two groups. Group 1 comprised patients with no history of fractures (n =13), and group 2 comprised patients with a history of fractures (n =17). All patients were evaluated in terms of their lumbar spine and femoral neck BMD (g/cm²) and parameters of calcium and phosphate metabolism.

Results: The evaluated groups showed no differences in terms of such parameters as neck left femur BMD (0.947±0.135 vs. 0.931±0.113, P = 0.934), total left femur BMD (0.975±0.115 vs. 0.932±0.141, P = 0.408), L1 BMD (1.242±0.252 vs. 1.113±0.147, P = 0.113), L2 BMD (1.296±0.198 vs. 1.202±0.195, P = 0.157), L3 BMD (1.359±0.205 vs. 1.264±0.188, P = 0.123), L4 BMD (1.280±0.200 vs. 1.244±0.194, P = 0.483), or L1–L4 BMD (0.129±0.206 vs. 1.212±0.171, P = 0.263). There was no significant correlation between a history of fractures and femoral neck BMD (Spearman’s R -0.016, P = 0.935), total (Spearman’s R -0.159, P = 0.4), or L1–L4 (Spearman’s R -2.09, P = 0.266).

Conclusions: A history of fractures in patients with classical or hypermobile EDS is not associated with significantly lower BMD in such locations as neck and total left femur or L1–L4.