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Endocrine Abstracts (2025) 110 EP309 | DOI: 10.1530/endoabs.110.EP309

ECEESPE2025 ePoster Presentations Bone and Mineral Metabolism (142 abstracts)

Waddling gait and parathyroid adenoma: what to have in mind for a quick diagnosis?

Merita Emini Sadiku 1,2,3 , Zana Vela Gaxha 1,2 , Granit Xhiha 4 , Adem Rama 1 , Nadije Morina Kuci 2 & Ardiana Perjuci Begolli 2


1University of Prishtina “Hasan Prishtina”, Medical Faculty, Clinic of Endocrinology, Prishtina, Kosovo, Prishtina, Kosovo; 2University Clinical Center of Kosova, Clinic of Endocrinology, Prishtina, Kosovo; 3Policlinics “endoCLINIC medical & laboratory", Prishtina, Kosovo; 4Regional Hospital of Gjakova, Department of Neurology, Gjakova, Kosovo


JOINT2432

Parathyroid adenoma often remains undiagnosed for a relatively long time, due to the fact that bone pains and disorders of the osteomuscular system, patients seek to be resolved in other non-endocrinological problems. Case presentation: The case describes a primary thyroid adenoma in a 46-year-old patient with a two-year history of upper and lower limb pain, treated by a rheumatologist as polyathralgia without signs of improvement from therapy! In the meantime, the patient is also diagnosed with severe osteoporosis. The neurologist who was consulted for a headache during the neck examination noticed a mass in the lower part of the neck and in the ultrasound a nodule was seen for which he was referred to the endocrinologist (Figure 1). After the corresponding laboratory and imaging examinations, the patient is diagnosed with very high PTH, high calcium(Table 1) bilateral nephrocalcinosis (Figure 2), marked osteoporosis (Figure 3), fractures of the lumbar vertebrae (Figure 4), bones with diffuse osteolytic foci (Figure 5) and parathyroid adenoma, together with the expressed and characteristic clinical waddling gait from lumbar fractures and myopathy lead to primary hyperparathyroidism from parathyroid adenoma. The patient is referred for surgery and for a short time he was being fully recovered and normal gait of walking.

Key Words: Parathyroid adenoma, parathyroid hormone, hypercalcemia, bone pain

References: 1. Yang CA, Lin JL, Dai SH, Cheng SP. Double water-clear cell parathyroid adenoma: a case report and literature review. Endocr J. 2022 Jun 28;69(6):717-724. doi: 10.1507/endocrj.EJ21-0590. Epub 2022 Jan 6. PMID: 34987145. 2. Mahmodlou R, Sedokani A, Pezeshk A, Najafinejad B. Giant parathyroid adenoma: a case report. J Med Case Rep. 2022 Apr 13;16(1):150. doi: 10.1186/s13256-022-03401-y. PMID: 35414046; PMCID: PMC9006466. 3. Giunta R, Ferrario S, Zanoli L, Orlando S, Conti A, Benintende D, Castiglione G, Rapisarda F. [Giant parathyroid adenoma: a rare cause of severe hypercalcemia]. G Ital Nefrol. 2020 Apr 9;37(2):2020-vol2. Italian. PMID: 32281761. 4. Al-Hassan MS, Mekhaimar M, El Ansari W, Darweesh A, Abdelaal A. Giant parathyroid adenoma: a case report and review of the literature. J Med Case Rep. 2019 Nov 14;13(1):332. doi: 10.1186/s13256-019-2257-7. PMID: 31722742; PMCID: PMC6854700. 5. Boro H, Alam S, Kubihal V, Khatiwada S, Kubihal S, Agarwal S, Khadgawat R. Atypical parathyroid adenoma: Severe manifestations in an adolescent girl. Pediatr Endocrinol Diabetes Metab. 2022;28(1):91-100. doi: 10.5114/pedm.2021.109127. PMID: 35193332; PMCID: PMC10226359.

Volume 110

Joint Congress of the European Society for Paediatric Endocrinology (ESPE) and the European Society of Endocrinology (ESE) 2025: Connecting Endocrinology Across the Life Course

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