Endocrine Abstracts

JOINT3921

Introduction and Objectives: Diabetes mellitus is a highly prevalent disease that can affect nutritional status, as well as quality of life and functioning. The present study aims to evaluate the differences in nutritional status, by analysing functionality parameters and quality of life scales, in patients with diabetes and disease-related malnutrition (DRE) or high nutritional risk, at baseline and 3 months after starting specific nutritional supplementation.

Material and Methods: We selected 15 patients assessed in nutritional prehabilitation consultations, with a diagnosis of type 2 diabetes mellitus and digestive cancer, with DRE or high nutritional risk according to GLIM criteria, in active oncological treatment (chemotherapy, surgery). A nutritional support programme was initiated with dietary recommendations, exercise and specific supplementation for people with type 2 diabetes. Anthropometric assessments, functional tests (number of squats performed in 10 seconds, up and go test) and scales (diabetes stress scale, EQ-5D-5L) were performed at the first consultation and at a 3-month review. Differences were analysed using SSPS v.24 statistical software. A value of P<0.05 was considered statistically significant and trend to statistical significance P<0.1.

Results: Mean age 71.3 years (SDS 8.2). Antidiabetic treatment received by patients: 69% metformin, 31% iDPP4, 23% iSGLT2, 15% slow insulin, 8% rapid insulin, 8% sulphonylureas. Subjective global assessment at baseline was 61.5% moderate and 15.4% severe malnutrition. At 3 months, 46.2% were moderately malnourished and 53.8% were normonnourished. At 3 months after the start of nutritional supplementation, calf diameter had increased from baseline by a statistically significant 34.4cm vs 35.2cm (P<0.05). Diabetes stress scale scores 7.6 vs 4.2 points (NS) and EQ-5D-5L 7 vs 7.6 (NS) also improved. Functional tests of squats and TUG improved modestly 8.8 vs 10.1 squats (NS) and 10.9 vs 10 seconds (P<0.05). There was no change in dynamometry results 29.5 vs 29.1 kg (NS).

Conclusions: The implementation of a nutritional support programme in routine medical practice, based on dietary recommendations, exercise and specific supplementation for people with type 2 diabetes with malnutrition or high nutritional risk, improved functional outcomes and subjective assessment in our cohort of oncology patients.